Quercus coccinea Münchh leaves polyphenols: Appraisal acute lung injury induced by lipopolysaccharide in mice - 17/06/23
Abstract |
Genus Quercus is a well-known source for its polyphenolic content and important biological activity. Plants belonging to the Quercus genus were traditionally used in asthma, inflammatory diseases, wound healing, acute diarrhea, and hemorrhoid. Our work intended to study the polyphenolic profile of the Q. coccinea (QC) leaves and to assess the protective activity of its 80% aqueous methanol extract (AME) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Together, the potential molecular mechanism was investigated. Nineteen polyphenolic compounds (1–18), including tannins, flavone, and flavonol glycosides. Phenolic acids and aglycones were purified and identified from the AME of QC leaves. Treatment with AME of QC showed an anti-inflammatory effect evidenced by a remarkable decline in the count of white blood cells and neutrophils which was in harmony with decreasing the levels of high mobility group box-1, nuclear factor kappa B, tumor necrosis factor-α, and interleukin 1 beta. In addition, the antioxidant activity of QC was documented through the significant reduction in malondialdehyde level and elevation of reduced glutathione level and superoxide dismutase activity. Furthermore, the mechanism involved in the pulmonary protective effect of QC involved the downregulation of the TLR4/MyD88 pathway. The AME of QC showed a protective effect against LPS-induced ALI through the powerful anti-inflammatory and antioxidant activities which are linked to its abundancy with polyphenols.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
● | Quercus coccinea was used traditionally in asthma, inflammation diseases. |
● | Polyphenols are characterized by many biological activities. |
● | Lung injury was induced by lipopolysaccharide in mice. |
● | QC attenuates lung inflammation by modulating the MyD88-dependent TLR4 signaling. |
● | QC exhibited antioxidant activity via modulating oxidative stress/NF-κB signaling. |
Keywords : Anti-inflammatory, Quercus coccinea, Polyphenols, Lipopolysaccharide, TLR4, Oxidative stress, NF-κB, Lung injury
Plan
Vol 164
Article 114765- août 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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