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Journal of the American Academy of Dermatology
Volume 2, n° 4
pages 318-321 (avril 1980)
Doi : 10.1016/S0190-9622(80)80044-2
Clinical and laboratory studies

Topically applied erythromycin in inflammatory acne vulgaris

Joel E. Bernstein, M.D. 1, 2, , Alan R. Shalita, M.D. 1, 2
1 From the University of Chicago, Division of the Biological Sciences, and the Pritzker School of Medicine, Department of Medicine, Section of Dermatology, Ch 
2 Division of Dermatology, Downstate Medical Center, Brooklyn, USA 

3Reprint requests to: Dr. Joel E. Bernstein, 950 East 59th St., Box 409, Chicago, IL 60637.

We evaluated the effectiveness of 2% erythromycin and its alcohol/propylene glycol vehicle in the treatment of three hundred forty-eight patients with inflammatory acne vulgaris. A significantly greater reduction was noted in the papulopustule count for the erythromycin-treated group compared to the vehicle-treated group. Additionally, clinical improvement, as measured by physician global ratings, was significantly greater in the erythromycin-treated group. A lower adverse reaction rate observed in the erythromycin-treated patients may result from previously demonstrated anti-inflammatory properties of this antibiotic.

The full text of this article is available in PDF format.

* This research was supported by the Wellman fund.

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