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Neurochirurgie
Volume 65, n° 1
pages 43-48 (février 2019)
Doi : 10.1016/j.neuchi.2018.09.004
Received : 14 Mars 2018 ;  accepted : 23 September 2018
Cas cliniques courts

A case of brain metastasis of a thymic carcinoma with a review of the literature
 

R. Kouitcheu a, , R. Appay b, M. Diallo a, L. Troude a, A. Melot a
a Department of neurosurgery, CHU-hôpital Nord, Marseille, France 
b Department of pathology and neuropathology, CHU-Timone, Marseille, France 

Corresponding author.
Abstract

Thymic epithelial tumors (TET) are rare lesions. The brain metastases of these tumors are even rarer. We report a case of brain metastases in a known patient with a thymic carcinoma diagnosed in October 2016. She was a 73-year-old woman who presented with headache, nausea, and right hemiplegia. Brain MRI revealed five lesions (1 insular, 1 frontal and 2 left temporal, 1 right parafalcine). These lesions were initially treated using two stereotactic radiosurgery gamma knives. A macroscopically complete excision of the left frontal lesion was subsequently performed without any complications with a good evolution of the neurological symptoms postoperatively. Immunohistochemical examination was compatible with metastatic thymic carcinoma. The patient died 14 months after the initial diagnosis. A review of the literature in English has reported another 45 TET cases with brain metastases.

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Keywords : Brain metastases, Thymic carcinoma, Stereotactic radiosurgery




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