5 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text

Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

Journal of the American Academy of Dermatology
Volume 80, n° 6
pages 1730-1745 (juin 2019)
Doi : 10.1016/j.jaad.2018.11.029
accepted : 7 November 2018

Platelet-rich plasma and its utility in the treatment of acne scars: A systematic review

Michael J. Hesseler, MD a, , Nikhil Shyam, MD b
a Department of Dermatology, University of Michigan, Ann Arbor, Michigan 
b Department of Dermatology, Johns Hopkins University, Baltimore, Maryland 

Correspondence to: Michael J. Hesseler, MD, University of Michigan Department of Dermatology, Michigan Medicine, 1500 E Medical Center Dr, Floor 1, Reception B, Ann Arbor, MI 48109.University of Michigan Department of Dermatology, Michigan Medicine1500 E Medical Center Dr, Floor 1, Reception BAnn ArborMI48109

The field of dermatology has seen numerous therapeutic innovations in the past decade, with platelet-rich plasma recently garnering significant interest in acne scarring. This review consolidates the available evidence on platelet-rich plasma for the practicing dermatologist and evaluates the current evidence up to May 31, 2018. A search was conducted in the PubMed database for the terms platelet-rich plasma or platelet releasate or platelet gel or PRP and dermatology or skin or acne or scar or cutaneous , with 13 articles meeting the inclusion criteria. The quality of each individual study was evaluated, and levels of evidence were assigned according to the Centre for Evidence-Based Medicine, Oxford, United Kingdom. This review reveals that activated, leukocyte- and platelet-rich plasma in combination with fractional ablative laser treatment administered in 2 or 3 sequential sessions 1 month apart improves the appearance of acne scars. The evidence for the use of platelet-rich plasma with microneedling is less supportive. Because of the heterogeneity of the studies and widely variable outcome measures, comparison between platelet-rich plasma treatments and subsequent statistical analysis could not be performed. Although these studies use various subjective and objective evaluation methods, the addition of platelet-rich plasma provides improvements in acne scarring, higher patient satisfaction, and decreased postprocedure downtime.

The full text of this article is available in PDF format.

Key words : acne, acne scars, dermatology, platelet-rich plasma

Abbreviations used : AA-L-PRP, AA-P-PRP, L-PRP, NA-L-PRP, PRP, TCA

 Funding sources: None.
 Conflicts of interest: None disclosed.
 Reprints not available from the authors.

© 2018  Published by Elsevier Masson SAS.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline