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Journal of the American Academy of Dermatology
Volume 80, n° 6
pages 1780-1782 (juin 2019)
Doi : 10.1016/j.jaad.2018.12.020
Research Letters

Tumor mutational burden and response to programmed cell death protein 1 inhibitors in a case series of patients with metastatic desmoplastic melanoma

Lise Boussemart, MD, PhD a, b, Adrienne Johnson, MSc c, Alexa B. Schrock, PhD, MD c, Sumanta K. Pal, MD d, Garrett M. Frampton, PhD c, David Fabrizio, BS c, Zachary Chalmers c, Michal Lotem, MD e, Geoffrey Gibney, MD f, Jeffery Russell, MD g, Bartosz Chmielowski, MD, PhD h, Jeffrey S. Ross, MD c, i, Phil J. Stephens, PhD c, Vincent A. Miller, MD c, Siraj M. Ali, MD, PhD c,
a Department of Dermatology, Pontchaillou Hospital, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France 
b Université Rennes, Centre National de la Recherche Scientifique, Institut de Génétique and Développement de Rennes, UMR 6290, F-35000 Rennes, France 
c Foundation Medicine Inc, Cambridge, Massachusetts 
d Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, California 
e Department of Oncology, Hadassah Medical Center, Jerusalem, Israel 
f Georgetown-Lombardi Comprehensive Cancer Center, Washington DC 
g Moffitt Cancer Center, Tampa, Florida 
h Department of Medicine, Jonsson Comprehensive Cancer Center at the University of California Los Angeles, Los Angeles, California 
i Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York 

Correspondence to: Siraj M. Ali, MD, PhD, Foundation Medicine Inc, 150 Second St, Second Floor, Cambridge, MA 02141Foundation Medicine Inc150 Second StSecond FloorCambridgeMA02141

 Dr Ross is currently affiliated with Upstate Medical University's Department of Pathology and Laboratory Medicine. Dr Russell is currently affiliated with Janssen Pharmaceuticals.
 Dr Boussemart, Ms Johnson, and Dr Schrock contributed to this work equally.
 Funding sources: None.
 Conflicts of interest: Ms Johnson, Dr Schrock, Dr Frampton, Mr Fabrizio, Mr Chalmers, Dr Ross, Dr Stephens, Dr Miller, and Dr Ali were employed by and held equity interest in Foundation Medicine Inc at the time this study was performed. Foundation Medicine Inc is now a wholly owned subsidiary of Roche. Dr Lotem is an employee of TEVA Pharmaceuticals. Dr Boussemart, Dr Pal, Dr Gibney, Dr Chmielowski, and Dr Russell have no conflicts of interest to disclose.
 Reprints not available from the authors.

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