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Gynécologie Obstétrique & Fertilité
Volume 36, n° 3
pages 248-260 (mars 2008)
Doi : 10.1016/j.gyobfe.2008.01.004
Received : 15 January 2008 ;  accepted : 21 January 2008
Infection congénitale à Cytomégalovirus (CMV)
Cytomegalovirus (CMV) congenital infection
 

G. Benoist a, F. Jacquemard a, M. Leruez-Ville b, Y. Ville a,
a Service de gynécologie–obstétrique, centre hospitalier intercommunal (CHI) de Poissy Saint-Germain, 10, rue du Champ-Gaillard, 78300 Poissy, France 
b Laboratoire de virologie, CHU de Necker-Enfants-Malades, AP–HP, 149, rue de Sèvres, 75015 Paris, France 

Auteur correspondant.
Résumé

Le Cytomégalovirus humain (HCMV) est la principale cause de retard mental et de déficit auditif liés aux infections congénitales. La justification d’un dépistage systématique de l’infection à CMV en cours de grossesse est encore controversée et n’est pas recommandée dans la plupart des pays développés. Cette attitude se justifie principalement par le manque de facteurs pronostiques anténatals et l’absence de traitement utilisable durant la vie fœtale. Notre objectif était de synthétiser l’état actuel des connaissances sur l’infection congénitale à CMV et de mettre en lumière les avancées récentes concernant, notamment, l’identification des facteurs pronostiques et les possibilités thérapeutiques à venir.

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Abstract

Human Cytomegalovirus (CMV) is the main cause of mental retardation and sensorineural hearing loss related to congenital infections. Justification of systematic screening for fetal CMV infection is still controversial and is not recommended in most developed countries. This is mainly justified by the paucity of antenatal prognostic factors and the lack of established intrauterine treatment when fetal infection has been diagnosed. Our aim was to review the current state of the knowledge about the CMV congenital infection and to highlight recent advances in the diagnosis as well as in the identification of prognostic factors.

The full text of this article is available in PDF format.

Mots clés : Cytomégalovirus (CMV), Infection congénitale, Diagnostic prénatal, Pronostic, Traitement

Keywords : Cytomegalovirus (CMV), Congenital infection, Prenatal diagnosis, Prognosis, Treatment




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