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Annales de Dermatologie et de Vénéréologie
Volume 137, n° 12
pages 803-807 (décembre 2010)
Doi : 10.1016/j.annder.2010.08.010
Received : 9 February 2010 ;  accepted : 25 August 2010
Infiltrat lymphocytaire de Jessner et Kanof traité par laser à colorant pulsé
Pulsed dye laser treatment for Jessner’s lymphocytic infiltration of the skin
 

J.-L. Michel a, , D. Perrin b
a Cabinet de dermatologie, avenue résidence v, 14, place des grenadiers-quartier-grouchy, 42000 Saint-Étienne, France 
b Cabinet de dermatologie, 67000 Strasbourg, France 

Auteur correspondant.
Résumé
Introduction

L’infiltrat lymphocytaire bénin, ou maladie de Jessner et Kanof (MJK), est une affection rare et bénigne, de traitement difficile.

Observations

Cinq patients présentaient une MJK clinique. Dans tous les cas, la biopsie cutanée montrait un infiltrat lymphocytaire dense de toute la hauteur du derme, à disposition périvasculaire et périannexielle ; les examens complémentaires écartaient les diagnostics différentiels possibles. Les patients étaient traités par laser à colorant pulsé 595 nm avec une fluence de 5,5 à 8 J/cm2 et une durée de tir de 0,5 msec, avec une régression en une séance dans trois cas et deux à trois séances dans deux cas.

Discussion

À notre connaissance, un seul cas de traitement de la MJK par laser à colorant pulsé a été publié jusqu’ici. Le laser à colorant pulsé est utilisé dans certaines formes de lupus cutané et de granulome annulaire. La photothermolyse sélective permet l’ablation des capillaires dilatés impliqués dans l’érythème et l’inflammation.

Conclusion

Le laser à colorant pulsé 595nm pourrait être une alternative intéressante, y compris en première intention, pour cette maladie affichante mais sans conséquence générale.

The full text of this article is available in PDF format.
Summary
Background

Jessner’s lymphocytic infiltration of the skin (LIS) is a chronic, benign T-cell infiltrative disorder, usually manifesting as erythematous papules or plaques on the face, neck and back.

Patients and methods

Five patients presented LIS with numerous skin lesions on the face and back characteristic of this disease. Histological examination showed a lymphocytic infiltrate in the dermis without any modification of the epidermis. Direct immunofluorescent study was negative in all cases. Response to dermocorticoids proved inconsistent or negative in all patients. An excellent outcome was achieved in all five patients with pulsed dye laser. In one case, further skin lesions appeared at 1year and responded to the same treatment. Following a single treatment session with 6–8 J/cm2, three of five patients showed normal skin. Regression occurred in the other two cases after two to three sessions. Pulsed dye laser appeared to be the best treatment for Jessner-Kanof disease for three patients at 4–8years of follow-up.

Discussion

Only one case of Jessner-Kanof disease treated by pulsed dye laser has been reported. Pulsed dye laser has been used in cutaneous lupus and annular granuloma. Selective photothermolysis allows photocoagulation of dilated vessels.

Conclusion

Pulsed dye laser at 595nm could offer a valuable therapeutic alternative, and even a first-line treatment with no side effects.

The full text of this article is available in PDF format.

Mots clés : Infiltrat lymphocytaire bénin, Maladie de Jessner et Kanof, Laser à colorant pulsé

Keywords : Jessner’s lymphocytic infiltration of the skin, Pulsed dye laser




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