Article

8 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

  • You can purchase this item in Pay Per ViewPay per View - FAQ : 30,00 € Taxes included to order
    Pages Iconography Videos Other
    6 8 0 0


Archives de pédiatrie
Volume 18, n° 2
pages 238-243 (février 2011)
Doi : 10.1016/j.arcped.2010.10.016
Un nouvel éclairage physiopathologique de la modulation de la réponse immune par les lactobacilles
New in light of immune modulation by probiotics bacteria and increase IL10 producing regulatory T cells
 

J.-P. Magny
Service de pneumologie et allergologie clinique, hôpital Armand-Trousseau, 26, avenue du Docteur-Arnold-Netter, 75571 Paris cedex 12, France 

Résumé

Les études faites avec les probiotiques avaient retrouvé un bénéfice lors de leur utilisation que l’on attribuait à un effet barrière de la muqueuse intestinale. On tente ici une nouvelle explication physiopathologique étayée par des résultats murins et, chez l’homme. Les récepteurs DC-SIGN et TOLL de la cellule dendritique interfèrent dans la coprésentation d’antigènes et suscitent une modulation de la réponse immune par les cellules T régulatrices et leurs cytokines inhibitrices TGFβ et IL10.

The full text of this article is available in PDF format.
Abstract

Studies on probiotics had found a benefit in their use. That was attributed to a barrier effect at the intestinal mucosa. We tried a new immunephysiological explanation supported by murine works and in humans. Immune modulation by probiotic bacteria and induce IL10 producing regulatory T cells. Receptors DCSIGN and Toll dendrites cells interfere in the copresentation of antigens and generate an immune response modulation by regulatory T cells and their inhibitory cytokines TGFβ, IL10.

The full text of this article is available in PDF format.


© 2010  Elsevier Masson SAS. All Rights Reserved.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline