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Journal of the American Academy of Dermatology
Volume 44, n° 4
pages 629-633 (avril 2001)
Doi : 10.1067/mjd.2001.110896
“High-dose” UVA1 therapy of widespread plaque-type, nodular, and erythrodermic mycosis fungoides

Cristina Zane, MDa, Carla Leali, MDa, Paolo Airò, MDb, Giuseppe De Panfilis, MDa, Piergiacomo Calzavara Pinton, MDa
Brescia, Italy 
From the Dermatology Department, Azienda Spedali Civili di Brescia,a and the Institute of Immunology,b University of Brescia 


Background: UVA1 (340 to 400 nm) was found to be effective in the treatment of early-stage mycosis fungoides (MF). Objective: The purpose of this study was to assess the efficacy of UVA1 phototherapy for widespread plaque-type, nodular, and erythrodermic MF. Methods: Thirteen patients (8 with stage IB, 4 with IIB, and 1 with III MF) received 100 J/cm2 UVA1 daily until remission. Four patients also had lesions inaccessible by UVA1 that were considered control lesions. Immunocytologic studies of skin infiltrates and circulating T cells were done before and after the therapy. Results: Eleven patients showed complete clinical and histologic responses. Two patients had a partial improvement. Unirradiated control lesions never improved. Serious short-term side effects were not recorded. Circulating CD4+/CD45RO+ and CD4+/CD95+ lymphocytes were significantly reduced by the therapy. Conclusion: UVA1 therapy is an effective and well-tolerated treatment for advanced MF. The therapeutic relevance of the effects on circulating lymphocytes remains to be established because lesions in nonexposed cutaneous areas did not respond.

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 Reprint requests: Cristina Zane, MD, Department of Dermatology, Azienda Spedali Civili, P.le Spedali Civili 1,25123 Brescia, Italy.
 J Am Acad Dermatol 2001;44:629-33

© 2001  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@
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