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Journal of the American Academy of Dermatology
Volume 44, n° 4
pages 710-713 (avril 2001)
Doi : 10.1067/mjd.2001.112916
Clonal CD8+ infiltration of the skin in common variable immunodeficiency: A prelymphomatous stage?

Angelo V. Marzano, MD a, Emilio Berti, MD b, Elvio Alessi, MD a, Ruggero Caputo, MD a
a Institute of Dermatological Sciences, University of Milan and IRCCS Ospedale Maggiore Milan, Italy 
b University of Milan “Bicocca.” Milan, Italy 


Common variable immunodeficiency is a heterogeneous syndrome characterized by hypogammaglobulinemia and recurrent bacterial infections. Patients with this syndrome also have an increased incidence of autoimmune disease and malignancy, most notably lymphoproliferative disorders. The treatment for common variable immunodeficiency is supported by the use of intravenous infusion of immunoglobulins that allows for control of the disease and avoidance of recurrent opportunistic infections. This report describes a young patient having common variable immunodeficiency who presented with a clonal CD8+ lymphocytic infiltration of the skin clinically manifesting as a widespread papulonodular eruption and resolving with intravenous immunoglobulin therapy. We speculate that such a unique cutaneous presentation may represent a prelymphomatous condition because of the development of an autonomous T-suppressor/cytotoxic cell clone, possibly also responsible for the impaired immunoglobulin production. (J Am Acad Dermatol 2001;44:710-3.)

The full text of this article is available in PDF format.

 Reprint requests: Angelo V. Marzano, MD, Istituto di Scienze Dermatologiche, Via Pace, 9-20122 Milano, Italy.
 J Am Acad Dermatol 2001;44:710-3

© 2001  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@
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