Copper allergy revisited - 02/09/11
Abstract |
Background: Positive patch tests to copper sulfate are regularly observed, although copper is reported as a rare allergen with a low sensitizing potential. Usually they are claimed to be irritant and unspecific. Objective: The aim of this study was to assess the relevance and the diagnostic value of positive reactions to copper. Methods: A total of 2660 routine patch tests were analyzed for positive reactions to copper and other metal allergens: copper, 3.53%; nickel, 21.02%; palladium, 5.90%; cobalt, 3.31%. Results: Reactions to copper and nickel were highly significantly associated with each other. Twenty-six patients with a positive routine test to copper were retested. The reproducibility was modest (38%), but again significantly associated with nickel sensitization. Conclusion: These clinical data support a copper-nickel cross-reactivity concept on T-cell level based on recently published molecular data. We conclude that positive patch tests to copper are mostly specific; however, they are usually of low clinical relevance. (J Am Acad Dermatol 2001;45:863-70.)
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Funding: None. |
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Conflict of interest: None. |
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Reprint requests: Stefan Wöhrl, FAZ—Floridsdorf Allergy Centre, Franz-Jonas-Platz 8/6, A-1210 Vienna, Austria. |
Vol 45 - N° 6
P. 863-870 - décembre 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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