Isotretinoin improves the appearance of photodamaged skin: Results of a 36-week, multicenter, double-blind, placebo-controlled trial - 05/09/11
Abstract |
Photodamaged skin occurs as a result of long-term exposure to ultraviolet radiation. The incidence of photodamage in European and North American populations with Fitzpatrick skin types I, II, and III is estimated at 80% to 90%. We conducted a double-blind clinical trial to test the efficacy and safety of 0.1% isotretinoin versus vehicle cream in 800 patients with moderate to severe photodamaged skin. Patients applied either 0.1% isotretinoin or matching vehicle cream to the face, forearms, and hands once nightly for 36 weeks. Local irritation and adverse events were assessed, and plasma retinoid levels were measured before and during treatment. Treatment response increased throughout the 36-week treatment period and the overall appearance of photodamaged skin was significantly better than with the vehicle alone. Topical application of 0.1% isotretinoin is an effective and well-tolerated treatment leading to clinically apparent improvement in the appearance of photodamaged skin of the face, forearms, and hands. (J Am Acad Dermatol 2000;42:56-63.)
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*A list of the investigators of the Photodamage International Collaborative Study Group and their affiliations can be found at the end of this article. |
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Reprint requests: Stuart Maddin, MD, University of British Columbia, Division of Dermatology, Faculty of Medicine, Skin Care Center, Vancouver, British Columbia V5Z 4E8, Canada. |
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0190-9622/2000/$12.00 + 0 16/1/102357 |
Vol 42 - N° 1P1
P. 56-63 - janvier 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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