Childhood- and later-onset vitiligo have diverse epidemiologic and clinical characteristics - 13/05/12
, Christina Antoniou, MD, PhD, Alexandra Miniati, MD, Eirini Lagogianni, MD, Athina Matekovits, MD, Alex Stratigos, MD, PhD, Andreas Katsambas, MD, PhD
Reprint requests: Electra Nicolaidou, MD, PhD, First Department of Dermatology, University of Athens School of Medicine, 21 Leonidiou Str, GR-14564 Athens, Greece.Abstract |
Background |
Vitiligo onset during childhood is common. There are limited data regarding childhood-onset vitiligo.
Objective |
We sought to provide an epidemiologic and clinical comparison between childhood- and later-onset vitiligo.
Methods |
Two groups of patients were included in this cross-sectional study. Consecutive patients examined at the Vitiligo Clinic of Andreas Sygros Hospital for Skin and Venereal Diseases, Athens, Greece, from January 2005 to December 2009 with a disease onset before the age of 12 years were included in the childhood-onset group. The later-onset group included randomly selected patients who were examined at the same period and had a disease onset after the age of 12 years. After clinical examination, a standardized questionnaire was completed for each patient.
Results |
In all, 126 patients were included in the childhood-onset and 107 patients in the later-onset group. Childhood-onset vitiligo: (1) involved different sites at initial presentation, (2) included more cases of segmental type, and (3) was characterized by a higher prevalence of allergic diseases and a lower prevalence of thyroid diseases. Longer duration of disease and a positive family history of thyroid disease were associated with the presence of thyroid disease only in the childhood-onset group. In the later-onset group, only female sex was associated with the presence of thyroid disease.
Limitations |
The study was conducted in a hospital specializing in skin diseases and a selection bias toward more severe vitiligo cases is possible.
Conclusions |
Childhood-onset vitiligo had distinct epidemiologic and clinical characteristics, compared with later-onset disease.
Le texte complet de cet article est disponible en PDF.Key words : childhood vitiligo, clinical presentation, epidemiology, thyroid disease
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 66 - N° 6
P. 954-958 - juin 2012 Retour au numéro
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