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Archives of cardiovascular diseases
Volume 105, n° 6-7
pages 373-385 (juin 2012)
Doi : 10.1016/j.acvd.2012.02.010
Received : 23 December 2011 ;  accepted : 7 February 2012
Three key proteases – angiotensin-I-converting enzyme (ACE), ACE2 and renin – within and beyond the renin-angiotensin system
Protéases clés du système rénine-angiotensine : enzyme de conversion de l’angiotensine 1 et 2 et rénine
 

Figure 1




Figure 1 : 

Schematic representation of the primary structures of sACE, gACE, ACE2 and collectrin [6]. ACE: angiotensin-I-converting enzyme; gACE: germinal ACE; HEXXH: His-Glu-X-X-His; sACE: somatic ACE.


Figure 2




Figure 2 : 

Multiple effector systems of the renin-angiotensin system. ACE: angiotensin-I-converting enzyme; ACE2: angiotensin-I-converting enzyme 2; AGT: angiotensinogen; AMPA: aminopeptidase A; AMPM: aminopeptidase A; Ang I: angiotensin I; Ang II: angiotensin II; AT1R: angiotensin II receptor, type 1; AT2R: angiotensin II receptor, type 2; IRAP: insulin-regulated aminopeptidase; NEP: neutral endopeptidase; PEP: prolyl endopeptidase.

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