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Annales médico-psychologiques
Volume 172, n° 3
pages 192-196 (mai 2014)
Doi : 10.1016/j.amp.2014.02.012
Imagerie cérébrale et lithium
Neuroimaging and lithium
 

Chloé Benizri a, Josselin Houenou a, b, c, , d
a Inserm, U955, IMRB, équipe 15, « psychiatrie génétique », 94000 Créteil, France 
b Fondation fondamental, 94000 Créteil, France 
c Pôle de psychiatrie, hôpitaux universitaires Mondor, AP–HP, 40, rue de Mesly, 94000 Créteil, France 
d Uniact, Neurospin, I2BM, CEA, Gif-Sur-Yvette, France 

Auteur correspondant.
Résumé

Les techniques récentes de neuroimagerie, en particulier l’IRM cérébrale, permettent de mieux comprendre le mécanisme d’action du lithium. Nous présentons dans cet article une synthèse des principaux résultats sur la neuroimagerie du lithium chez les patients atteints de trouble bipolaire de l’humeur. L’imagerie cérébrale apporte en effet de nombreux arguments pour penser que l’action thérapeutique du lithium serait associée à un effet neurotrophique, en particulier sur la substance grise et l’hippocampe. Ces études soulèvent également des espoirs à moyen terme d’utilisation de l’IRM cérébrale dans la mesure de la lithiémie intracérébrale en spectroscopie, et l’aide à la prédiction de la réponse au lithium.

The full text of this article is available in PDF format.
Abstract
Objectives

Recent neuroimaging techniques like MRI, allow a better understanding of the mechanism of action of lithium. In this article, we summarize the main results about neuroimaging and lithium in bipolar disorder.

Methods

We selected relevant literature about brain imaging and lithium action in bipolar disorder.

Results and conclusions

Brain imaging studies bring evidence that lithium therapeutic effect is associated with a neurotrophic effect, especially in the grey matter and the hippocampus. They also raise hopes that we may in the future use brain imaging to measure directly brain lithium concentrations with spectroscopy and to help the clinician predict the response to lithium.

The full text of this article is available in PDF format.

Mots clés : Hippocampe, Imagerie par résonance magnétique, Neurobiologie, Pharmacodynamie, Sel de lithium, Système nerveux, Trouble bipolaire

Keywords : Bipolar disorder, Hippocampus, Lithium citrate, Magnetic resonance imaging, Neurobiology, Nervous system, Pharmacodynamics




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