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• • ·Cover 1

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• • ·Brief Overview of This Month’s JACI

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• • ·Table of Contents

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    Plan Plan  
• • ·This month’s theme

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• • ·About the cover

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• • ·In-press articles

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• • ·Symbols used in the Table of Contents

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• • ·Editorial Board

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    Plan Plan

• Reader services

  • ·Information for Readers

    Page :A29

    Plan Plan
  • ·Newsview-AAAAI

    Page :A31

    Plan Plan
  • ·CME Activities Calendar

    Page :A39

    Plan Plan

• News beyond our pages

  • ·News Beyond Our Pages

    Page :545

    Marc E. Rothenberg, Harold S. Nelson

    Plan Plan  

• Reviews and feature articles

  • ·Clinical assessment of asthma progression in children and adults

    Page :548-557

    Joseph D. Spahn, Ronina Covar

    Résumé Résumé Plan Plan
  • ·Clinical assessment of asthma progression in children and adults

    Page :558-559

    
  • ·Immunologic and inflammatory mechanisms that drive asthma progression to remodeling

    Page :560-570

    David H. Broide

    Résumé Résumé Plan Plan  
  • ·Immunologic and inflammatory mechanisms that drive asthma progression to remodeling

    Page :571-572

    

• Current perspectives

  • ·Interpatient variability in rates of asthma progression: Can genetics provide an answer?

    Page :573-579

    John W. Holloway, Ian A. Yang, Stephen T. Holgate

    Résumé Résumé Plan Plan

• Update review

  • ·The role of histone deacetylases in asthma and allergic diseases

    Page :580-584

    Pankaj Bhavsar, Tehireem Ahmad, Ian M. Adcock

    Résumé Résumé Plan Plan  

• Rostrums

  • ·The health effects of nonindustrial indoor air pollution

    Page :585-591

    Jonathan A. Bernstein, Neil Alexis, Hyacinth Bacchus, I. Leonard Bernstein, Pat Fritz, Elliot Horner, Ning Li, Stephany Mason, Andre Nel, John Oullette, Kari Reijula, Tina Reponen, James Seltzer, Alisa Smith, Susan M. Tarlo

    Résumé Résumé Plan Plan
  • ·Guide for interpreting reports from inspections/investigations of indoor mold

    Page :592

    W. Elliott Horner, Charles Barnes, Rosa Codina, Estelle Levetin

    Résumé Résumé Plan Plan  

• Overview editorial

  • ·Asthma progression: Can we and should we measure it?

    Page :598-600

    Stanley J. Szefler

    Plan Plan  

• Editorials

  • ·What the 21st century does not know about asthma—yet

    Page :601-602

    Charles E. Reed

    
  • ·Usefulness and optimization of mouse models of allergic airway disease

    Page :603-606

    Fred D. Finkelman, Marsha Wills-Karp

    

• Workshop summary

  • ·Natural history of asthma: Persistence versus progression—does the beginning predict the end?

    Page :607-613

    Reynold A. Panettieri, Ronina Covar, Evalyn Grant, Elizabeth V. Hillyer, Leonard Bacharier

    Résumé Résumé Plan Plan  

• Advances in Asthma, Allergy, and Immunology Series 2008

  • ·Advances in pediatric asthma in 2007

    Page :614-619

    Stanley J. Szefler

    Résumé Résumé Plan Plan  

• The Editors' choice

  • ·The Editors’ Choice

    Page :620-621

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

    Plan Plan  

• Editors' choice articles

  • ·Children’s respiratory health and mold levels in New Orleans after Katrina: A preliminary look

    Page :622-625

    Felicia A. Rabito, Shahed Iqbal, Michael P. Kiernan, Elizabeth Holt, Ginger L. Chew

    Résumé Résumé Plan Plan  
  • ·Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma

    Page :626-631

    Kara L. McDonald, Shamima I. Huq, Lisa M. Lix, Allan B. Becker, Anita L. Kozyrskyj

    Résumé Résumé Plan Plan
  • ·Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center

    Page :632

    Colin W. Summers, Richard S. Pumphrey, Charlotte N. Woods, Garry McDowell, Philip W. Pemberton, Peter D. Arkwright

    Résumé Résumé Plan Plan  
  • ·Geographic variability in childhood asthma prevalence in Chicago

    Page :639

    Ruchi S. Gupta, Xingyou Zhang, Lisa K. Sharp, John J. Shannon, Kevin B. Weiss

    Résumé Résumé Plan Plan  
  • ·Sensitization does not develop in utero

    Page :646-651

    Klaus Bønnelykke, Christian Bressen Pipper, Hans Bisgaard

    Résumé Résumé Plan Plan  
  • ·Increased activation-induced cell death of high IFN-γ–producing T_H1 cells as a mechanism of T_H2 predominance in atopic diseases

    Page :652

    Tunc Akkoc, Pieter J.A. de Koning, Beate Rückert, Isil Barlan, Mübeccel Akdis, Cezmi A. Akdis

    Résumé Résumé Plan Plan  

• Asthma and lower airway disease

  • ·TGFB1 promoter polymorphism C-509T and pathophysiology of asthma

    Page :659-664

    Tetsuya Ueda, Akio Niimi, Hisako Matsumoto, Masaya Takemura, Masafumi Yamaguchi, Hirofumi Matsuoka, Makiko Jinnai, Kazuo Chin, Masayoshi Minakuchi, Lei Cheng, Taro Shirakawa, Michiaki Mishima

    Résumé Résumé Plan Plan  
  • ·Reducing asthma health disparities in poor Puerto Rican children: The effectiveness of a culturally tailored family intervention

    Page :665-670

    Glorisa Canino, Doryliz Vila, Sharon-Lise T. Normand, Edna Acosta-Pérez, Rafael Ramírez, Pedro García, Cynthia Rand

    Résumé Résumé Plan Plan  
  • ·Aeroallergen sensitization correlates with PC₂₀ and exhaled nitric oxide in subjects with mild-to-moderate asthma

    Page :671-677

    Timothy J. Craig, Tonya S. King, Robert F. Lemanske, Michael E. Wechsler, Nikolina Icitovic, Ronald R. Zimmerman, Stephen Wasserman, National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network

    Résumé Résumé Plan Plan  
  • ·Exposure to multiple indoor allergens in US homes and its relationship to asthma

    Page :678

    Päivi M. Salo, Samuel J. Arbes, Patrick W. Crockett, Peter S. Thorne, Richard D. Cohn, Darryl C. Zeldin

    Résumé Résumé Plan Plan  
  • ·Increased sputum and bronchial biopsy IL-13 expression in severe asthma

    Page :685-691

    Shironjit K. Saha, Mike A. Berry, Deborah Parker, Salman Siddiqui, Angela Morgan, Richard May, Phillip Monk, Peter Bradding, Andrew J. Wardlaw, Ian D. Pavord, Christopher E. Brightling

    Résumé Résumé Plan Plan  
  • ·Increased T-cell survival by structural bronchial cells derived from asthmatic subjects cultured in an engineered human mucosa

    Page :692-699

    Marie-Eve Darveau, Eric Jacques, Mahmoud Rouabhia, Qutayba Hamid, Jamila Chakir

    Résumé Résumé Plan Plan  
  • ·Rapid corticosteroid effect on β₂-adrenergic airway and airway vascular reactivity in patients with mild asthma

    Page :700-704

    Eliana S. Mendes, Gabor Horvath, Michael Campos, Adam Wanner

    Résumé Résumé Plan Plan  
  • ·Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptoms

    Page :705-709

    Alexander Moeller, Corinne Diefenbacher, Andrea Lehmann, Mascha Rochat, Joanne Brooks-Wildhaber, Graham L. Hall, Johannes H. Wildhaber

    Résumé Résumé Plan Plan  
  • ·Does exhaled nitric oxide measurement help distinguish between wheezing phenotypes in preschool children?

    Page :710-711

    Leonard B. Bacharier

    
  • ·Safety of segmental allergen challenge in human allergic asthma

    Page :712-717

    Peter Julius, Marek Lommatzsch, Michael Kuepper, Kai Bratke, Sebastian Faehndrich, Werner Luttmann, Johann Christian Virchow

    Résumé Résumé Plan Plan  

• Rhinitis, sinusitis, and upper airway disease

  • ·Contribution of allergen-specific and nonspecific nasal responses to early-phase and late-phase nasal responses

    Page :718-724

    Satoko Miyahara, Nobuaki Miyahara, Joseph J. Lucas, Anthony Joetham, Shikegi Matsubara, Hiroshi Ohnishi, Azzeddine Dakhama, Erwin W. Gelfand

    Résumé Résumé Plan Plan  

• Atopic dermatitis and skin disease

  • ·Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity

    Page :725

    Jayanta Gupta, Emilie Grube, Mark B. Ericksen, Michelle D. Stevenson, Anne W. Lucky, Anita P. Sheth, Amal H. Assa’ad, Gurjit K. Khurana Hershey

    Résumé Résumé Plan Plan  

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Early clinical predictors of remission of peanut allergy in children

    Page :731-736

    Marco H.K. Ho, Wilfred H.S. Wong, Ralf G. Heine, Clifford S. Hosking, David J. Hill, Katrina J. Allen

    Résumé Résumé Plan Plan  
  • ·Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy

    Page :737

    Annebeth E. Flinterman, Edward F. Knol, Doerthe A. Lencer, Ludmilla Bardina, Constance F. den Hartog Jager, Jing Lin, Suzanne G.M.A. Pasmans, Carla A.F.M. Bruijnzeel-Koomen, Hugh A. Sampson, Els van Hoffen, Wayne G. Shreffler

    Résumé Résumé Plan Plan  
  • ·Identification of wheat gliadins as an allergen family related to baker’s asthma

    Page :744-749

    Cordula Bittner, Britta Grassau, Karsten Frenzel, Xaver Baur

    Résumé Résumé Plan Plan  

• Mechanisms of allergy and clinical immunology

  • ·Interactive effects of steroids and β-agonists on accumulation of type 2 T cells

    Page :750.e1

    Matthew J. Loza, Susan Foster, Stephen P. Peters, Raymond B. Penn

    Résumé Résumé Plan Plan  
  • ·Targeting Fel d 1 to FcγRI induces a novel variation of the T_H2 response in subjects with cat allergy

    Page :756

    Kathryn E. Hulse, Amanda J. Reefer, Victor H. Engelhard, Shama M. Satinover, James T. Patrie, Martin D. Chapman, Judith A. Woodfolk

    Résumé Résumé Plan Plan  

• Environmental allergens

  • ·Analytical bias of cross-reactive polyclonal antibodies for environmental immunoassays of Alternaria alternata

    Page :763-768

    Detlef Schmechel, Brett J. Green, Francoise M. Blachere, Erika Janotka, Donald H. Beezhold

    Résumé Résumé Plan Plan  

• Letters to the Editor

  • ·Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population

    Page :769-770

    Tomomitsu Hirota, Michishige Harada, Masafumi Sakashita, Satoru Doi, Akihiko Miyatake, Kimie Fujita, Tadao Enomoto, Motohiro Ebisawa, Shigemi Yoshihara, Emiko Noguchi, Hirohisa Saito, Yusuke Nakamura, Mayumi Tamari

     
  • ·How readable are the American Academy of Allergy, Asthma & Immunology “Tips to Remember” leaflets?

    Page :770-773

    Helen Smith, Jo Wade, Anthony Frew

    
  • ·Helminthic infection as a factor in new-onset coffee allergy in a father and daughter

    Page :773-774

    Giorgio Ciprandi, Enrico Cavallucci, Franco Cuccurullo, Mario Di Gioacchino

    
  • ·Patients’ characteristics associated with unsuccessful sputum induction in asthma

    Page :774-776

    Hirofumi Matsuoka, Akio Niimi, Hisako Matsumoto, Tetsuya Ueda, Masaya Takemura, Masafumi Yamaguchi, Makiko Jinnai, Liang Chang, Kojiro Otsuka, Tsuyoshi Oguma, Tomoshi Takeda, Kazuo Chin, Michiaki Mishima

    
  • ·The economic effect of the hydrofluoroalkane albuterol transition on children with asthma

    Page :776-777

    Harvey L. Leo, Kevin J. Dombkowski, Noreen M. Clark

    
  • ·Recall antigen reactions in patients with atopic dermatitis treated with tacrolimus ointment for 1 year

    Page :777-779

    Johanna Mandelin, Anita Remitz, Hannele Virtanen, Sakari Reitamo

     

• Correspondence

  • ·Benefits of combination therapy on exacerbations in nonsmoking patients with asthma

    Page :780

    Catherine Jackson, Brian Lipworth

    
  • ·Reply

    Page :780

    Søren E. Pedersen, Eric D. Bateman

    
  • ·Relationship between total and specific IgE in patients with asthma from Siberia

    Page :781

    Elena S. Gusareva, Lyudmila M. Ogorodova, Boris A. Chernyak, Marie Lipoldová

    
  • ·Reply

    Page :781-782

    Elizabeth A. Erwin, Thomas A.E. Platts-Mills

    
  • ·Vitamin D deficiency and asthma: Not a strong link—yet

    Page :782-783

    Jürgen Schauber, Richard L. Gallo

    
  • ·Reply

    Page :783-784

    Augusto A. Litonjua, Scott T. Weiss

    
  • ·Omalizumab also successful in chronic urticaria

    Page :784

    Sheldon L. Spector, Ricardo A. Tan

    
  • ·Reply

    Page :784-785

    Mark F. Sands, Jessica W. Blume, Stanley A. Schwartz

    
  • ·Delayed allergic reactions to omalizumab: Are patients reporting all cases?

    Page :785-786

    Peter J. Barry, Ann O’Mahony, Collette Finnegan, Terence M. O’Connor

     
  • ·Reply

    Page :786

    Susan L. Limb, Charles E. Lee, Peter R. Starke, Badrul A. Chowdhury

    

• The allergy archives: Pioneers and milestones

  • ·Blocking asthmatic progression and chronicity in the precorticosteroid era

    Page :787-790

    Sheldon G. Cohen

     

• Addendum

  • ·T-Cell Intracellular Antigen-1 is a Novel Regulator of IL-13 Production and Tissue Pathology in a Dust Mite-Mediated Asthma Model

    Page :791

    G. Giannattasio, M. Simarro, J.A. Boyce, P. Anderson

    Plan Plan
  • ·Regulation of IL-5 Receptor Endosomal Trafficking by Ubiquitin

    Page :791

    M. Moczygemba, J.T. Lei, D.S. Smith

    Plan Plan
  • ·TSLP Directly Inhibits IL-10 Expression By Human Regulatory T Cells

    Page :791

    K. Nguyen, K.C. Nadeau

    Plan Plan
  • ·Cys-Leukotrienes (cysLTs) Stimulate the Expression of Vascular Endothelial Growth Factor (VEGF)

    Page :791-792

    S. Poulin, C. Thompson, C.M. Dubois, J. Stankova, M. Rola-Pleszczynski

    Plan Plan
  • ·Is Eosinophil Dependence of Pulmonary Allergic Inflammation in Mice Really Strain Specific?

    Page :792

    S.I. Ochkur, E.A. Jacobsen, C. Protheroe, R.S. Pero, K.R. O’Neill, A.G. Taranova, D.C. Colbert, A. Doyle, C.G. Irvin, N.A. Lee, J.J. Lee

    Plan Plan
  • ·Estrogen Inhibits Corticosteroid Induction of the Mitogen-Induced Kinase Phosphatase Gene

    Page :792

    Y. Zhang, E. Goleva, D.Y.M. Leung

    Plan Plan
  • ·A Novel Strategy in Prevention and Delay of Type I Diabetes Mellitus (T1DM) Onset by Autoimmunization

    Page :792

    M.S. Lin, C. Wong, S. Bertera, J. Pignelli, H. Tse, M. Pietroppaolo, M. Milton, L. He, Y. Chang, Y. Zhang, R. Lakomy, J. Chang, M. Trucco

    Plan Plan
  • ·Changes and Significance of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in Peripheral Blood of Rats with Experimental Silicosis

    Page :792-793

    Q. Sha, C. Li, W. Zhu, T. Hu

    Plan Plan
  • ·Epicutaneous Is As Efficient As Subcutaneous Desensitization In A Mouse Model Of Allergy

    Page :793

    P. Benhamou, L. Mondoulet, D. Soury, M. Lagranderie, J. Ronco, C. Dupont

    Plan Plan
  • ·Abnormal T Lymphocyte Patterns In Chronic Rhinosinusitis With Nasal Polyps In A Chinese Population

    Page :793

    H. Li

    Plan Plan
  • ·Sublingual Immunotherapy With Honeybee Venom Is Effective In Patients With Large Local Reactions Due To Bee Sting. A Randomised, Double Blind Placebo Controlled Trial

    Page :793

    G. Passalacqua, M.G. Severino, G. Cortellini, P. Bonadonna, E. Francescato, I. Panzini, D. Macchia, P. Campi, I. Spadolini, G.W. Canonica

    
  • ·Long-Lasting Effect According to the Duration of Sublingual Immunotherapy: A 15-Year Prospective Study

    Page :793-794

    G.W. Canonica, M. Marogna, I. Spadolini, A. Massolo, G. Passalacqua

    Plan Plan
  • ·Acid Blocking Therapy During Pregnancy Increases the Odds for Childhood Asthma

    Page :794

    E.H. Yen, E. Dehlink, S. Huh, A. Leichtner, E. Fiebiger, E.J. Hait

    Plan Plan
  • ·Up-dosing of Desloratadine Reduces Cold Provocation Test Responses in Patients with Cold Urticaria

    Page :794

    M. Maurer, F. Siebenhaar, F. Degener, T. Zuberbier, P. Martus

    Plan Plan
  • ·A Randomized Controlled Trial (RCT) of the Effectiveness of Parent Mentors in Improving Asthma Outcomes in Minority Children

    Page :794

    G. Flores, C. Snowden-Bridon, S. Torres, R. Perez, T. Walter, J. Brotanek, S. Tomany-Korman

    Plan Plan
  • ·Treatment of Acute Abdominal and Facial Attacks of Hereditary Angioedema (HAE) with Human C1 Esterase Inhibitor (C1-INH): Results of a Global, Multicenter, Randomized, Placebo-controlled, Phase II/III Study (I.M.P.A.C.T.1)

    Page :795

    J.A. Bernstein, R. Levy, R.L. Wasserman, A. Bewtra, D. Hurewitz, K. Obtulowicz, A. Reshef, P.C. Kiessling, T.J. Craig

    Plan Plan
  • ·The Pattern and Progression of Multiple Tree Nut Allergy in Preschool Children

    Page :795

    K.J. Allen, M. Ho, W. Wong, R. Heine, C. Hosking, D. Hill

    Plan Plan
  • ·The Association between Frequent Large Local Reactions and Systemic Reactions to Immunotherapy within a Practice Utilizing a No-dose Adjustment Protocol for Local Reactions

    Page :795

    M.S. Tankersley, C.W. Calabria

    Plan Plan
  • ·Effect of Air Pollution on Asthma Severity and Control

    Page :795-796

    P. Huynh, K. Kwong, A. Ratanayake, T. Morphew, C. Jones

    Plan Plan
  • ·Recombinant Peanut Allergens: Specific IgEs for Diagnosis

    Page :796

    G. Kanny, F. Codreanu, S. Jacquenet, C. Astier, M. Morisset, D. Moneret-Vautrin, C. Roland, B. Bihain

    Plan Plan
  • ·CD34⁺ Precursor Cells are Potent Effectors of Allergic Inflammation

    Page :796

    Z. Allakhverdi, D.E. Smith, M.R. Comeau, G.J. Delespesse

    Plan Plan
  • ·Nasal Immunization With A Novel Nanonemulsion Adjuvant Modifies Th2-polarized Immune Responses

    Page :796

    J.R. Baker, K.W. Janczak, A.U. Bielinska

    Plan Plan
  • ·Secondhand cigarette smoke may combine with common respiratory viruses to trigger exaggerated inflammation in CRS

    Page :796-797

    D.L. Hamilos, M. Yamin, E. Holbrook, N. Busaba, S. Gray, K.J. Powell, R. Harold, A. Sridhar

    Plan Plan
  • ·Oral Desensitization to Peanut Monitored by the Follow-Up of IgEs to Recombinant Major Allergens Ara h 1 Ara h 2 Ara h 3

    Page :797

    A.D. Moneret-Vautrin, S. Jacquenet, C. Astier, B. Bihain

    Plan Plan
  • ·Clinical Studies of Recombinant Human C1 Inhibitor (rhC1INH) in Patients with Acute Attacks of Hereditary Angioedema

    Page :797

    J. Nuijens, R. Verdonk, B. Giannetti, S. Visscher, M. van Doorn, T. Resink, M. Levi, C. Hack, H. Farkas, K. Obtulowicz, T. Caballero, M. Cicardi

    Plan Plan
  • ·Mepolizumab, A Humanised Anti-IL-5 Monoclonal Antibody, As Treatment Of Severe Nasal Polyposis

    Page :797

    P. Gevaert, N. Van Bruaene, K. Blomme, A.R. Sousa, R.P. Marshal, C. Bachert

    Plan Plan
  • ·Soy Consumption Is Associated With Peanut Sensitisation; Cause Or Confounding?

    Page :797-798

    J. Koplin, S. Dharmage, L. Gurrin, N. Osborne, M. Tang, A. Lowe, C. Hosking, D. Hill, K.J. Allen

    Plan Plan
  • ·Dramatically Impaired Th17 Production In Patients With Stat3-Mutation Positive Hyper-ige Syndrome.

    Page :798

    J.D. Milner, J. Brenchley, A.F. Freeman, S.M. Holland, W.E. Paul, D.C. Douek

    Plan Plan
  • ·Pharmacogenetic Identification of Increased Responsiveness in Severe Asthma with anti-TNF (Golimumab) Therapy

    Page :798

    D.A. Meyers, G.A. Hawkins, S.A. Wenzel, K. Lo, R. Watt, E.R. Bleecker

    Plan Plan
  • ·Statewide Newborn Screening Program for Severe Combined Immunodeficiency (SCID) by Quantitating T-cell Receptor Excision Circles (TRECs)

    Page :798

    W.J. Grossman, J.M. Routes, R.H. Laessig, M.W. Baker

    Plan Plan
  • ·Late-Breaking Abstract Author Disclosures

    Page :e1