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• • ·Cover 1

    Page :OFC

    
• • ·A Brief Overview of This Month’s JACI

    Page :1A

    
• • ·Table of Contents

    Page :4A

    
• • ·Editorial Board

    Page :24A

    Plan Plan

• Reader services

  • ·Information for Readers

    Page :27A

    Plan Plan
  • ·Footnotes¹

    Page :28A

    Plan Plan  
  • ·CME Activities Calendar

    Page :33A

    Plan Plan

• News beyond our pages

  • ·News Beyond Our Pages

    Page :395-396

    Marc E. Rothenberg, Harold S. Nelson

    Plan Plan  

• Reviews and feature articles

  • ·Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma

    Page :397-403

    Paul M. O’Byrne, Gail M. Gauvreau, Desmond M. Murphy

    Résumé Résumé Plan Plan  
  • ·Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma

    Page :404-405

    
  • ·The leukotriene E₄ puzzle: Finding the missing pieces and revealing the pathobiologic implications

    Page :406-414

    K. Frank Austen, Akiko Maekawa, Yoshihide Kanaoka, Joshua A. Boyce

    Résumé Résumé Plan Plan  
  • ·The leukotriene E₄ puzzle: Finding the missing pieces and revealing the pathobiologic implications

    Page :415-416

    
  • ·Leukotriene E₄: Perspective on the forgotten mediator

    Page :417-421

    Tak H. Lee, Grzegorz Woszczek, Sophie P. Farooque

    Résumé Résumé Plan Plan  
  • ·Genetics and pharmacogenetics of the leukotriene pathway

    Page :422-427

    Kelan G. Tantisira, Jeffrey M. Drazen

    Résumé Résumé Plan Plan  
  • ·Unmet needs in severe chronic upper airway disease (SCUAD)

    Page :428-433

    Jean Bousquet, Claus Bachert, Giorgio W. Canonica, Thomas B. Casale, Alvaro A. Cruz, Richard J. Lockey, Torsten Zuberbier, on behalf of the extended Global Allergy and Asthma European Network, World Allergy Organization and Allergic Rhinitis and its Impact on Asthma Study Group §

    Résumé Résumé Plan Plan

• The Editors' choice

  • ·The Editors’ Choice

    Page :434-435

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

    Plan Plan  

• Asthma and lower airway disease

  • ·Randomized trial of the effect of drug presentation on asthma outcomes: The American Lung Association Asthma Clinical Research Centers

    Page :436

    Robert A. Wise, Susan J. Bartlett, Ellen D. Brown, Mario Castro, Rubin Cohen, Janet T. Holbrook, Charles G. Irvin, Cynthia S. Rand, Marianna M. Sockrider, Elizabeth A. Sugar, American Lung Association Asthma Clinical Research Centers ∗

    Résumé Résumé Plan Plan  
  • ·The placebo effect in asthma: Far more complex than simply “I shall please”

    Page :445-446

    William W. Busse, Robert F. Lemanske

    Plan Plan  
  • ·Total IgE levels and asthma prevalence in the US population: Results from the National Health and Nutrition Examination Survey 2005-2006

    Page :447-453

    Peter J. Gergen, Samuel J. Arbes, Agustin Calatroni, Herman E. Mitchell, Darryl C. Zeldin

    Résumé Résumé Plan Plan  
  • ·Activin and transforming growth factor-β signaling pathways are activated after allergen challenge in mild asthma

    Page :454-462

    Harsha H. Kariyawasam, Sophie Pegorier, Julia Barkans, Georgina Xanthou, Maxine Aizen, Sun Ying, A. Barry Kay, Clare M. Lloyd, Douglas S. Robinson

    Résumé Résumé Plan Plan  
  • ·Elucidation of asthma phenotypes in atopic teenagers through parallel immunophenotypic and clinical profiling

    Page :463

    Elysia M. Hollams, Marie Deverell, Michael Serralha, Devinda Suriyaarachchi, Faith Parsons, Guicheng Zhang, Nicholas de Klerk, Barbara J. Holt, Claire Ladyman, Agata Sadowska, Julie Rowe, Richard Loh, Peter D. Sly, Patrick G. Holt

    Résumé Résumé Plan Plan  

• Rhinitis, sinusitis, and upper airway disease

  • ·Early onset of action of a 5-grass-pollen 300-IR sublingual immunotherapy tablet evaluated in an allergen challenge chamber

    Page :471

    Friedrich Horak, Petra Zieglmayer, René Zieglmayer, Patrick Lemell, Philippe Devillier, Armelle Montagut, Michel Mélac, Sylvie Galvain, Stéphanie Jean-Alphonse, Laurence Van Overtvelt, Philippe Moingeon, Martine Le Gall

    Résumé Résumé Plan Plan  
  • ·Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese

    Page :478

    Ping-Ping Cao, Hua-Bin Li, Bao-Feng Wang, Shui-Bin Wang, Xue-Jun You, Yong-Hua Cui, De-Yun Wang, Martin Desrosiers, Zheng Liu

    Résumé Résumé Plan Plan  

• Atopic dermatitis and skin disease

  • ·Filaggrin-deficient mice exhibit T_H17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen

    Page :485

    Michiko K. Oyoshi, George F. Murphy, Raif S. Geha

    Résumé Résumé Plan Plan  
  • ·Our evolving understanding of the functional role of filaggrin in atopic dermatitis

    Page :494-495

    Donald Y.M. Leung

    
  • ·Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

    Page :496

    Tiffany C. Scharschmidt, Mao-Qiang Man, Yutaka Hatano, Debra Crumrine, Roshan Gunathilake, John P. Sundberg, Kathleen A. Silva, Theodora M. Mauro, Melanie Hupe, Soyun Cho, Yan Wu, Anna Celli, Matthias Schmuth, Kenneth R. Feingold, Peter M. Elias

    Résumé Résumé Plan Plan  
  • ·Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum

    Page :507

    Pei-Song Gao, Nicholas M. Rafaels, Tracey Hand, Tanda Murray, Mark Boguniewicz, Tissa Hata, Lynda Schneider, Jon M. Hanifin, Richard L. Gallo, Li Gao, Terri H. Beaty, Lisa A. Beck, Kathleen C. Barnes, Donald Y.M. Leung

    Résumé Résumé Plan Plan  
  • ·Prognosis in adult indolent systemic mastocytosis: A long-term study of the Spanish Network on Mastocytosis in a series of 145 patients

    Page :514-521

    Luis Escribano, Iván Álvarez-Twose, Laura Sánchez-Muñoz, Andres Garcia-Montero, Rosa Núñez, Julia Almeida, Maria Jara-Acevedo, Cristina Teodósio, Mónica García-Cosío, Carmen Bellas, Alberto Orfao

    Résumé Résumé Plan Plan  

• Immune deficiencies, infection, and systemic immune disorders

  • ·Development of a routine newborn screening protocol for severe combined immunodeficiency

    Page :522-527

    Mei W. Baker, William J. Grossman, Ronald H. Laessig, Gary L. Hoffman, Charles D. Brokopp, Daniel F. Kurtycz, Michael F. Cogley, Thomas J. Litsheim, Murray L. Katcher, John M. Routes

    Résumé Résumé Plan Plan  
  • ·Fibronectin is a T_H1-specific molecule in human subjects

    Page :528

    Hilary Sandig, Joanne McDonald, Jane Gilmour, Matthew Arno, Tak H. Lee, David J. Cousins

    Résumé Résumé Plan Plan  
  • ·Comèl-Netherton syndrome defined as primary immunodeficiency

    Page :536-543

    Ellen D. Renner, Dominik Hartl, Stacey Rylaarsdam, Marguerite L. Young, Linda Monaco-Shawver, Gary Kleiner, M. Louise Markert, E. Richard Stiehm, Bernd H. Belohradsky, Melissa P. Upton, Troy R. Torgerson, Jordan S. Orange, Hans D. Ochs

    Résumé Résumé Plan Plan  

• Mechanisms of allergy and clinical immunology

  • ·Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations

    Page :544

    Anita H.J. van den Biggelaar, Susan L. Prescott, Marjut Roponen, Marie A. Nadal-Sims, Catherine J. Devitt, Suparat Phuanukoonnon, William Pomat, Meri K. Tulic, Deborah Lehmann, Peter M. Siba, Peter C. Richmond, Patrick G. Holt

    Résumé Résumé Plan Plan  
  • ·Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-κB pathways in rhinovirus-infected epithelial cells

    Page :551-557

    Rommy Koetzler, Raza S. Zaheer, Robert Newton, David Proud

    Résumé Résumé Plan Plan  
  • ·Lung mast cells are a source of secreted phospholipases A₂

    Page :558

    Massimo Triggiani, Giorgio Giannattasio, Cecilia Calabrese, Stefania Loffredo, Francescopaolo Granata, Alfonso Fiorello, Mario Santini, Michael H. Gelb, Gianni Marone

    Résumé Résumé Plan Plan  
  • ·Association of the cysteinyl leukotriene receptor 1 gene with atopy in the British 1958 birth cohort

    Page :566

    Nathalie P. Duroudier, David P. Strachan, John D. Blakey, Ian P. Hall

    Résumé Résumé Plan Plan  
  • ·Eosinophil-derived IFN-γ induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes

    Page :573

    Akira Kanda, Virginie Driss, Nicolas Hornez, Marwan Abdallah, Thomas Roumier, Georges Abboud, Fanny Legrand, Delphine Staumont-Sallé, Severine Quéant, Julie Bertout, Sébastien Fleury, Patrick Rémy, Jean-Paul Papin, Valérie Julia, Monique Capron, David Dombrowicz

    Résumé Résumé Plan Plan  
  • ·An IgE-associated polymorphism in STAT6 alters NF-κB binding, STAT6 promoter activity, and mRNA expression

    Page :583

    Michaela Schedel, Remo Frei, Christian Bieli, Lisa Cameron, Jerzy Adamski, Roger Lauener, Michael Kabesch

    Résumé Résumé Plan Plan  
  • ·Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy

    Page :590

    Hans Michael Haitchi, David J.P. Bassett, Fabio Bucchieri, Xiufeng Gao, Robert M. Powell, Neil A. Hanley, David I. Wilson, Stephen T. Holgate, Donna E. Davies

    Résumé Résumé Plan Plan  

• Letters to the Editor

  • ·Self-reported allergic reactions to peanut and tree nuts occurring on commercial airlines

    Page :598-599

    Matthew J. Greenhawt, Marc S. McMorris, Terence J. Furlong

     
  • ·Rotavirus vaccine induced diarrhea in a child with severe combined immune deficiency

    Page :600

    Rebecca L. Werther, Nigel W. Crawford, Karen Boniface, Carl D. Kirkwood, Joanne M. Smart

    
  • ·Role of omalizumab and steroids in Churg-Strauss syndrome

    Page :600-601

    Maria Francesca Spina, Antonio Miadonna

    
  • ·Inadequate health literacy is associated with increased asthma morbidity in a population sample

    Page :601-603

    Robert J. Adams, Sarah L. Appleton, Catherine L. Hill, Richard E. Ruffin, David H. Wilson

    
  • ·Mammalian meat–induced anaphylaxis: Clinical relevance of anti–galactose-⍺-1,3-galactose IgE confirmed by means of skin tests to cetuximab

    Page :603-605

    Sandrine Jacquenet, Denise-Anne Moneret-Vautrin, Bernard E. Bihain

     
  • ·17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry

    Page :605-607

    James H. Flory, Patrick M. Sleiman, Jason D. Christie, Kiran Annaiah, Jonathan Bradfield, Cecilia E. Kim, Joseph Glessner, Marcin Imielinski, Hongzhe Li, Edward C. Frackelton, Hou Cuiping, George Otieno, Kelly Thomas, Ryan Smith, Wendy Glaberson, Maria Garris, Rosetta Chiavacci, Julian Allen, Jonathan Spergel, Robert Grundmeier, Michael Grunstein, Michael Magnusson, Struan F.A. Grant, Klaus Bønnelykke, Hans Bisgaard, Hakon Hakonarson

     
  • ·Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma

    Page :607

    Jose R. Cortes, Maria D. Rivas, Javier Molina-Infante, Maria A. Gonzalez-Nuñez, Moises Perez-G, Juan F. Masa, Juan F. Sanchez, Jose Zamorano

     
  • ·Open-label maintenance after milk oral immunotherapy for IgE-mediated cow’s milk allergy

    Page :610-612

    Satya D. Narisety, Justin M. Skripak, Pamela Steele, Robert G. Hamilton, Elizabeth C. Matsui, A. Wesley Burks, Robert A. Wood

    
  • ·T_H2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells

    Page :612

    Kanami Orihara, Hideaki Morita, Akiko Yagami, Naoki Kajiwara, Susumu Nakae, Kenji Matsumoto, Hiroshi Nagasaki, Yumiko Saito, Hirohisa Saito, Akio Matsuda

     
  • ·Consistency of sputum eosinophilia in difficult-to-treat asthma: A 5-year follow-up study

    Page :615

    Ilonka H. van Veen, Anneke ten Brinke, Stefanie A. Gauw, Peter J. Sterk, Klaus F. Rabe, Elisabeth H. Bel

     
  • ·Pulmonary nontuberculous mycobacterial infections in hyper-IgE syndrome

    Page :617-618

    Elizabeth Melia, Alexandra F. Freeman, Yvonne R. Shea, Amy P. Hsu, Steven M. Holland, Kenneth N. Olivier

     
  • ·Polymeric immunoglobulin receptor may link asthma with increased risk of pneumococcal disease

    Page :619

    Michael Eisenhut

    
  • ·Reply

    Page :619-620

    Young J. Juhn, Hirohito Kita, Barbara P. Yawn, Thomas G. Boyce, Robert M. Jacobson

    
  • ·Allergic or nonallergic rhinitis?

    Page :620

    Federica Di Berardino

    
  • ·Reply

    Page :620-621

    Carmen Rondón, Miguel Blanca

    
  • ·Correction

    Page :621