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• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

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• • ·Table of Contents

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• • ·Editorial Board

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• Reviews and feature articles

  • ·Therapeutic pipeline for atopic dermatitis: End of the drought?

    Page :633-643

    Amy S. Paller, Kenji Kabashima, Thomas Bieber

    Résumé Résumé Plan Plan  
  • ·Therapeutic pipeline for atopic dermatitis: End of the drought?

    Page :644

    
  • ·Psoriasis pathogenesis and the development of novel targeted immune therapies

    Page :645-653

    Jason E. Hawkes, Tom C. Chan, James G. Krueger

    Résumé Résumé Plan Plan  
  • ·Vitiligo: Mechanistic insights lead to novel treatments

    Page :654-662

    Michael L. Frisoli, John E. Harris

    Résumé Résumé Plan Plan  
  • ·Idiopathic systemic capillary leak syndrome (Clarkson disease)

    Page :663-670

    Kirk M. Druey, Samir M. Parikh

    Résumé Résumé Plan Plan  
  • ·Advances in asthma in 2016: Designing individualized approaches to management

    Page :671-680

    William C. Anderson, Andrea J. Apter, Cullen M. Dutmer, Daniel A. Searing, Stanley J. Szefler

    Résumé Résumé Plan Plan

• The Editors' choice

  • ·The Editors' Choice

    Page :681-682

    Cezmi A. Akdis, Zuhair K. Ballas, Associate Editors of the JACI

    Plan Plan  

• News beyond our pages

  • ·News Beyond Our Pages

    Page :683-684

    Marc E. Rothenberg, Jean Bousquet

    Plan Plan  

• Paradigms and perspectives

  • ·Phase 2 to phase 3 clinical trial transitions: Reasons for success and failure in immunologic diseases

    Page :685-687

    Dhavalkumar D. Patel, Christian Antoni, Steven J. Freedman, Marc C. Levesque, John S. Sundy

    Plan Plan  

• Editorial

  • ·Asthma: The past, future, environment, and costs

    Page :688-689

    Eyal Shemesh, Lawrence C. Kleinman

     

• Asthma and lower airway disease

  • ·Quantitative computed tomographic imaging–based clustering differentiates asthmatic subgroups with distinctive clinical phenotypes

    Page :690

    Sanghun Choi, Eric A. Hoffman, Sally E. Wenzel, Mario Castro, Sean Fain, Nizar Jarjour, Mark L. Schiebler, Kun Chen, Ching-Long Lin, National Heart, Lung and Blood Institute's Severe Asthma Research Program j

    Résumé Résumé Plan Plan  
  • ·Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis

    Page :701-709

    Woo-Jung Song, Hyun Jung Kim, Ji-Su Shim, Ha-Kyeong Won, Sung-Yoon Kang, Kyoung-Hee Sohn, Byung-Keun Kim, Eun-Jung Jo, Min-Hye Kim, Sang-Heon Kim, Heung-Woo Park, Sun-Sin Kim, Yoon-Seok Chang, Alyn H. Morice, Byung-Jae Lee, Sang-Heon Cho

    Résumé Résumé Plan Plan   
  • ·Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients

    Page :710-719

    Philip E. Silkoff, Michel Laviolette, Dave Singh, J. Mark FitzGerald, Steven Kelsen, Vibeke Backer, Celeste M. Porsbjerg, Pierre-Olivier Girodet, Patrick Berger, Joel N. Kline, Geoffrey Chupp, Vedrana S. Susulic, Elliot S. Barnathan, Frédéric Baribaud, Matthew J. Loza, Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study investigators I.StrambuS.LamA.EichA.Ludwig-SengpielR.LeighM.DransfieldW.CalhounA.HussainiP.Chanez, I. Strambu, S. Lam, A. Eich, A. Ludwig-Sengpiel, R. Leigh, M. Dransfield, W. Calhoun, A. Hussaini, P. Chanez

    Résumé Résumé Plan Plan   

• Rhinitis, sinusitis, and ocular allergy

  • ·Microparticles in nasal lavage fluids in chronic rhinosinusitis: Potential biomarkers for diagnosis of aspirin-exacerbated respiratory disease

    Page :720-729

    Toru Takahashi, Atsushi Kato, Sergejs Berdnikovs, Whitney W. Stevens, Lydia A. Suh, James E. Norton, Roderick G. Carter, Kathleen E. Harris, Anju T. Peters, Kathryn E. Hulse, Leslie C. Grammer, Kevin C. Welch, Stephanie Shintani-Smith, Bruce K. Tan, David B. Conley, Robert C. Kern, Bruce S. Bochner, Robert P. Schleimer

    Résumé Résumé Plan Plan   

• Atopic dermatitis and inflammatory skin disease

  • ·Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis

    Page :730-737

    Judith L. Thijs, Ian Strickland, Carla A.F.M. Bruijnzeel-Koomen, Stefan Nierkens, Barbara Giovannone, Eszter Csomor, Bret R. Sellman, Tomas Mustelin, Matthew A. Sleeman, Marjolein S. de Bruin-Weller, Athula Herath, Julia Drylewicz, Richard D. May, DirkJan Hijnen

    Résumé Résumé Plan Plan   

• Food allergy and gastrointestinal disease

  • ·Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis

    Page :738

    Mark Rochman, Jared Travers, Cora E. Miracle, Mary C. Bedard, Ting Wen, Nurit P. Azouz, Julie M. Caldwell, Kiran KC, Joseph D. Sherrill, Benjamin P. Davis, Jeffrey K. Rymer, Kenneth M. Kaufman, Bruce J. Aronow, Marc E. Rothenberg

    Résumé Résumé Plan Plan  

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis

    Page :750

    Peter Korosec, Paul J. Turner, Mira Silar, Peter Kopac, Mitja Kosnik, Bernhard F. Gibbs, Mohamed H. Shamji, Adnan Custovic, Matija Rijavec

    Résumé Résumé Plan Plan  

• Biologics and immunotherapy

  • ·Sialylated Fetuin-A as a candidate predictive biomarker for successful grass pollen allergen immunotherapy

    Page :759

    Noémie Caillot, Julien Bouley, Karine Jain, Sandrine Mariano, Sonia Luce, Stéphane Horiot, Sabi Airouche, Chloé Beuraud, Christian Beauvallet, Philippe Devillier, Sylvie Chollet-Martin, Christine Kellenberger, Laurent Mascarell, Henri Chabre, Thierry Batard, Emmanuel Nony, Vincent Lombardi, Véronique Baron-Bodo, Philippe Moingeon

    Résumé Résumé Plan Plan  

• Mechanisms of allergy/immunology

  • ·Shared genetic variants suggest common pathways in allergy and autoimmune diseases

    Page :771-781

    Eskil Kreiner, Johannes Waage, Marie Standl, Susanne Brix, Tune H. Pers, Alexessander Couto Alves, Nicole M. Warrington, Carla M.T. Tiesler, Elaine Fuertes, Lude Franke, Joel N. Hirschhorn, Alan James, Angela Simpson, Joyce Y. Tung, Gerard H. Koppelman, Dirkje S. Postma, Craig E. Pennell, Marjo-Riitta Jarvelin, Adnan Custovic, Nicholas Timpson, Manuel A. Ferreira, David P. Strachan, John Henderson, David Hinds, Hans Bisgaard, Klaus Bønnelykke

    Résumé Résumé Plan Plan   

• Translational and clinical immunology

  • ·Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes

    Page :782-796

    Meri Kaustio, Emma Haapaniemi, Helka Göös, Timo Hautala, Giljun Park, Jaana Syrjänen, Elisabet Einarsdottir, Biswajyoti Sahu, Sanna Kilpinen, Samuli Rounioja, Christopher L. Fogarty, Virpi Glumoff, Petri Kulmala, Shintaro Katayama, Fitsum Tamene, Luca Trotta, Ekaterina Morgunova, Kaarel Krjutškov, Katariina Nurmi, Kari Eklund, Anssi Lagerstedt, Merja Helminen, Timi Martelius, Satu Mustjoki, Jussi Taipale, Janna Saarela, Juha Kere, Markku Varjosalo, Mikko Seppänen

    Résumé Résumé Plan Plan   
  • ·Recognition of viral and self-antigens by T_H1 and T_H1/T_H17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses

    Page :797-808

    Moira Paroni, Virginia Maltese, Marco De Simone, Valeria Ranzani, Paola Larghi, Chiara Fenoglio, Anna M. Pietroboni, Milena A. De Riz, Maria C. Crosti, Stefano Maglie, Monica Moro, Flavio Caprioli, Riccardo Rossi, Grazisa Rossetti, Daniela Galimberti, Massimiliano Pagani, Elio Scarpini, Sergio Abrignani, Jens Geginat

    Résumé Résumé Plan Plan   
  • ·Abnormal CD161⁺ immune cells and retinoic acid receptor–related orphan receptor ?t–mediate enhanced IL-17F expression in the setting of genetic hypertension

    Page :809

    Madhu V. Singh, Michael Z. Cicha, Santosh Kumar, David K. Meyerholz, Kaikobad Irani, Mark W. Chapleau, François M. Abboud

    Résumé Résumé Plan Plan  

• Environmental and occupational disease

  • ·Urban residence, neighborhood poverty, race/ethnicity, and asthma morbidity among children on Medicaid

    Page :822-827

    Corinne A. Keet, Elizabeth C. Matsui, Meredith C. McCormack, Roger D. Peng

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• Epidemiology and health care delivery

  • ·Parents' childhood socioeconomic circumstances are associated with their children's asthma outcomes

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    Edith Chen, Madeleine U. Shalowitz, Rachel E. Story, Katherine B. Ehrlich, Erika M. Manczak, Paula J. Ham, Van Le, Gregory E. Miller

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  • ·Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy

    Page :836

    James E. Gern, Agustin Calatroni, Katy F. Jaffee, Henry Lynn, Amy Dresen, William W. Cruikshank, Howard M. Lederman, Hugh A. Sampson, Wayne Shreffler, Leonard B. Bacharier, Peter J. Gergen, Diane R. Gold, Meyer Kattan, George T. O'Connor, Megan T. Sandel, Robert A. Wood, Gordon R. Bloomberg

    Résumé Résumé Plan Plan  
  • ·Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial

    Page :845

    Annice Heratizadeh, Thomas Werfel, Andreas Wollenberg, Susanne Abraham, Sibylle Plank-Habibi, Christina Schnopp, Michael Sticherling, Christian Apfelbacher, Tilo Biedermann, Kristine Breuer, Isabel Fell, Regina Fölster-Holst, Guido Heine, Jennifer Grimm, Lars Hennighausen, Claudia Kugler, Imke Reese, Johannes Ring, Knut Schäkel, Jochen Schmitt, Kurt Seikowski, Esther von Stebut, Nicola Wagner, Anja Waßmann-Otto, Ute Wienke-Graul, Elke Weisshaar, Margitta Worm, Uwe Gieler, Joerg Kupfer

    Résumé Résumé Plan Plan  

• Letters to the Editor

  • ·?_S1-Casein elucidate major T-cell responses in cow's milk allergy

    Page :854

    L. Diego Archila, Fatima S. Khan, Nupur Bhatnagar, David Robinson, Mary L. Farrington, William W. Kwok

     
  • ·Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma

    Page :857-860

    Steven R. White, Jessie Nicodemus-Johnson, Bharathi Laxman, Darcy R. Denner, Edward T. Naureckas, D. Kyle Hogarth, Randi Stern, Alexa Minc, Julian Solway, Anne Sperling, Carole Ober

      
  • ·Airway microbiome and responses to corticosteroids in corticosteroid-resistant asthma patients treated with acid suppression medications

    Page :860

    Elena Goleva, J. Kirk Harris, Charles E. Robertson, Leisa P. Jackson, Richard J. Martin, Donald Y.M. Leung

     
  • ·CTLA-4 haploinsufficiency in a patient with an autoimmune lymphoproliferative disorder

    Page :862

    Zeynep Yesim Kucuk, Louis-Marie Charbonnier, Richard L. McMasters, Talal Chatila, Jack J. Bleesing

     
  • ·Omalizumab is effective in cold urticaria—results of a randomized placebo-controlled trial

    Page :864

    Martin Metz, Andrea Schütz, Karsten Weller, Marina Gorczyza, Sebastian Zimmer, Petra Staubach, Hans F. Merk, Marcus Maurer

     
  • ·IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

    Page :867

    Cristina Cunha, Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Luís Leite, Katrien Lagrou, António Marques, Carmen B. Lupiañez, Inês Mesquita, Joana Gaifem, Ana Margarida Barbosa, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Cornelia Lass-Flörl, Jürgen Löffler, Manuel Jurado, Margarida Saraiva, Oliver Kurzai, Fernando Rodrigues, António G. Castro, Ricardo Silvestre, Juan Sainz, Johan A. Maertens, Egídio Torrado, Ilse D. Jacobsen, João F. Lacerda, António Campos, Jr, Agostinho Carvalho

     
  • ·Omalizumab is effective in symptomatic dermographism—results of a randomized placebo-controlled trial

    Page :870

    Marcus Maurer, Andrea Schütz, Karsten Weller, Nicole Schoepke, Adriane Peveling-Oberhag, Petra Staubach, Sabine Müller, Thilo Jakob, Martin Metz

     
  • ·Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency

    Page :873

    Marcia A. Munoz, Julie Jurczyluk, Sam Mehr, Ryan C. Chai, Rob J.W. Arts, Angela Sheu, Chelsea McMahon, Jacqueline R. Center, Davinder Singh-Grewal, Jeffrey Chaitow, Dianne E. Campbell, Julian M.W. Quinn, Kirill Alexandrov, Zakir Tnimov, Stuart G. Tangye, Anna Simon, Tri Giang Phan, Michael J. Rogers

     
  • ·Ibrutinib, a Bruton’s tyrosine kinase inhibitor used for treatment of lymphoproliferative disorders, eliminates both aeroallergen skin test and basophil activation test reactivity

    Page :875

    Jennifer A. Regan, Yun Cao, Melanie C. Dispenza, Shuo Ma, Leo I. Gordon, Adam M. Petrich, Bruce S. Bochner

     
  • ·Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan

    Page :879

    Akiko Yagami, Michiko Aihara, Zenro Ikezawa, Michihiro Hide, Reiko Kishikawa, Eishin Morita, Yuko Chinuki, Yuma Fukutomi, Atsuo Urisu, Atsuki Fukushima, Yasuharu Itagaki, Shin-ichi Sugiura, Hiroyuki Tanaka, Reiko Teshima, Zenichiro Kato, Emiko Noguchi, Masashi Nakamura, Hirohisa Saito, Kayoko Matsunaga

     
  • ·Systems approach to uncover signaling networks in primary immunodeficiency diseases

    Page :881

    Jeff Choi, Rosemary Fernandez, Holden T. Maecker, Manish J. Butte

     
  • ·Hypersensitivity transfusion reactions due to IgA deficiency are rare according to French hemovigilance data

    Page :884-885

    Charles Tacquard, Karim Boudjedir, Monique Carlier, Jean-Yves Muller, Philippe Gomis, Paul Michel Mertes

     
  • ·The antimicrobial peptide human beta-defensin 2 promotes itch through Toll-like receptor 4 signaling in mice

    Page :885

    Jing Feng, Jialie Luo, Madison R. Mack, Pu Yang, Feng Zhang, Guan Wang, Xuan Gong, Tao Cai, Zhinan Mei, Brian S. Kim, Shijin Yin, Hongzhen Hu

     
  • ·Efficacy and safety of dupilumab for the treatment of adult atopic dermatitis: A meta-analysis of randomized clinical trials

    Page :888

    Yue Han, Yuxin Chen, Xiaochun Liu, Jingxi Zhang, Huichun Su, He Wen, Wei Li, Xu Yao

     
  • ·Assessment of thunderstorm-induced asthma using Google Trends

    Page :891

    Jean Bousquet, Robyn E. O'Hehir, Josep M. Anto, Gennaro D'Amato, Ralph Mösges, Peter W. Hellings, Michiel Van Eerd, Aziz Sheikh

     
  • ·Correction

    Page :894

    

• Reader services

  • ·Information for Readers

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  • ·News & Notes

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  • ·CME Activities Calendar

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