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• • ·Editorial Board

    Page :ii

    

• Review Articles

  • ·Neuropeptides and breathing in health and disease

    Page :217-224

    Katarzyna Kaczy?ska, Dominika Zaj?c, Piotr Wojciechowski, Ewelina Kogut, Ma?gorzata Szereda-Przestaszewska

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• Original Articles

  • ·Steroid sparing effects of doxofylline

    Page :1-4

    Yanira Riffo-Vasquez, Radhakrishnan Venkatasamy, Clive P. Page

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  • ·The leukotriene receptor antagonist pranlukast attenuates airway remodeling by suppressing TGF-? signaling

    Page :5-14

    Jung Hur, Ji Young Kang, Chin Kook Rhee, Young Kyoon Kim, Sook Young Lee

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  • ·The effect of l-Arginine on Ciliary Beat Frequency in PCD patients, non-PCD respiratory patients and healthy controls

    Page :15-21

    Panayiotis Kouis, Andreas Hadjisavvas, Nicos Middleton, Stefania I. Papatheodorou, Kyriacos Kyriacou, Panayiotis K. Yiallouros

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  • ·Size distribution of salbutamol/ipratropium aerosols produced by different nebulizers in the absence and presence of heat and humidification

    Page :22-27

    Ssu-Han Yang, Tsung-Ming Yang, Hui-Ling Lin, Ying-Huang Tsai, Tien-Pei Fang, Gwo-Hwa Wan

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  • ·Comparison of fluticasone/formoterol with budesonide/formoterol pMDI in adults with moderate to severe persistent asthma: Results from a 12-week randomized controlled trial

    Page :28-36

    Akash Balki, S. Balamurugan, Suhas Bardapurkar, Sonia Dalal, Ajeet Singh, B.P. Singh, Abhijit Vaidya, Jaideep A. Gogtay

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  • ·Long-acting ?2-adrenoreceptor agonists suppress type 1 interferon expression in human plasmacytoid dendritic cells via epigenetic regulation

    Page :37-45

    Chang-Hung Kuo, San-Nan Yang, Yi-Giien Tsai, Chong-Chao Hsieh, Wei-Ting Liao, Li-Chen Chen, Min-Sheng Lee, Hsuan-Fu Kuo, Ching-Hsiung Lin, Chih-Hsing Hung

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  • ·Inhibition of angiotensin II and calpain attenuates pleural fibrosis

    Page :46-52

    Lin-Jie Song, Fei Xiang, Hong Ye, Hai Huang, Jie Yang, Fan Yu, Liang Xiong, Juan-Juan Xu, Peter A. Greer, Huan-Zhong Shi, Jian-Bao Xin, Yunchao Su, Wan-Li Ma

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  • ·Phosphorylation of epidermal growth factor receptor at serine 1047 in cultured lung alveolar epithelial cells by bradykinin B2 receptor stimulation

    Page :53-61

    Shunsuke Izumi, Sayomi Higa-Nakamine, Hiroyuki Nishi, Hidetsugu Torihara, Ayako Uehara, Kazuhiro Sugahara, Manabu Kakinohana, Hideyuki Yamamoto

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  • ·Role of prostaglandin E₂ in bronchoconstriction-triggered cough response in guinea pigs

    Page :62-70

    Akihito Okazaki, Johsuke Hara, Noriyuki Ohkura, Masaki Fujimura, Tamami Sakai, Miki Abo, Nobuyuki Katayama, Kazuo Kasahara, Shinji Nakao

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  • ·Pharmacodynamics, pharmacokinetics and safety of revefenacin (TD-4208), a long-acting muscarinic antagonist, in patients with chronic obstructive pulmonary disease (COPD): Results of two randomized, double-blind, phase 2 studies

    Page :71-79

    Dean Quinn, Christopher N. Barnes, Wayne Yates, David L. Bourdet, Edmund J. Moran, Peter Potgieter, Andrew Nicholls, Brett Haumann, Dave Singh

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  • ·ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema

    Page :80-87

    Masafumi Nojiri, Shiro Mizuno, Kazuaki Nishiki, Ryo Kato, Ken Nakagawa, Taku Oikawa, Masaharu Iguchi, Kazuhiro Osanai, Takeshi Ishizaki, Hirohisa Toga

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  • ·Inhaled nebulised unfractionated heparin improves lung function in moderate to very severe COPD: A pilot study

    Page :88-96

    Janis K. Shute, Luigino Calzetta, Vittorio Cardaci, Stefania di Toro, Clive P. Page, Mario Cazzola

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  • ·Factors affecting the selection of an inhaler device for COPD and the ideal device for different patient profiles. Results of EPOCA Delphi consensus

    Page :97-103

    Marc Miravitlles, Juan José Soler-Cataluña, Bernardino Alcázar, José Luis Viejo, Francisco García-Río

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  • ·Glucocorticoids and ?₂-agonists regulate the pathologic metabolism of hyaluronic acid in COPD

    Page :104-110

    Eleni Papakonstantinou, Ioannis Klagas, George Karakiulakis, Michael Tamm, Michael Roth, Daiana Stolz

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  • ·Treatment with long acting muscarinic antagonists stimulates serum levels of irisin in patients with COPD

    Page :111-116

    Jyotshna Mandal, Michael Roth, Eleni Papakonstantinou, Qingzhu Sun, Luigi Costa, Lucas Boeck, Andreas Scherr, Janko Rakic, Renaud Louis, Branislava Milenkovic, Wim Boersma, Konstantinos Kostikas, Francesco Blasi, Joachim Aerts, Gernot Rohde, Alicia Lacoma, Antoni Torres, Tobias Welte, Michael Tamm, Daiana Stolz

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  • ·Activating prostaglandin E2 receptor subtype EP4 increases secreted mucin from airway goblet cells

    Page :117-123

    Tomohiro Akaba, Kosaku Komiya, Isao Suzaki, Yuji Kozaki, Jun Tamaoki, Bruce K. Rubin

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  • ·Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats

    Page :124-135

    Ruizan Shi, Zehui Wei, Diying Zhu, Naijie Fu, Chang Wang, Sha Yin, Yueqin Liang, Jianfeng Xing, Xuening Wang, Yan Wang

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  • ·Population pharmacokinetics of nintedanib in patients with idiopathic pulmonary fibrosis

    Page :136-143

    Ulrike Schmid, Christiane Doege, Claudia Dallinger, Matthias Freiwald

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  • ·M₃ receptor is involved in the effect of penehyclidine hydrochloride reduced endothelial injury in LPS-stimulated human pulmonary microvascular endothelial cell

    Page :144-150

    Qinghong Yuan, Fei Xiao, Qiangsheng Liu, Fei Zheng, Shiwen Shen, Qianwen He, Kai Chen, Yanlin Wang, Zongze Zhang, Jia Zhan

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  • ·Physicochemical, pharmacokinetic, efficacy and toxicity profiling of a potential nitrofuranyl methyl piperazine derivative IIIM-MCD-211 for oral tuberculosis therapy via in-silico–in-vitro–in-vivo approach

    Page :151-160

    Asmita Magotra, Anjna Sharma, Samsher Singh, Probir Kumar Ojha, Sunil Kumar, Naveen Bokolia, Priya Wazir, Shweta Sharma, Inshad Ali Khan, Parvinder Pal Singh, Ram A. Vishwakarma, Gurdarshan Singh, Utpal Nandi

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  • ·Tiotropium inhibits mucin production stimulated by neutrophil elastase but not by IL-13

    Page :161-167

    Kosaku Komiya, Shuichi Kawano, Isao Suzaki, Tomohiro Akaba, Jun-ichi Kadota, Bruce K. Rubin

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  • ·On the pharmacokinetics of two inhaled budesonide/formoterol combinations in asthma patients using modeling approaches

    Page :168-178

    K. Soulele, P. Macheras, V. Karalis

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  • ·Are valved holding chambers (VHCs) interchangeable? An in vitro evaluation of VHC equivalence

    Page :179-184

    Sanjeeva Dissanayake, Mark Nagel, Emanuela Falaschetti, Jason Suggett

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  • ·Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis

    Page :185-194

    Mario Cazzola, Luigino Calzetta, Clive Page, Paola Rogliani, Maria Gabriella Matera

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  • ·Hypoxic challenge of hyperoxic pulmonary artery myocytes increases oxidative stress due to impaired mitochondrial superoxide dismutase activity

    Page :195-202

    Iram Musharaf, Martha Hinton, Man Yi, Shyamala Dakshinamurti

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  • ·Effects of tiotropium bromide on airway hyperresponsiveness and inflammation in mice exposed to organic dust

    Page :203-210

    Joshua A. Gregory, Cecilia Kemi, Jie Ji, Jakob Karén, Ingrid Delin, Per Gerde, Michael P. Pieper, Mikael Adner, Kjell Larsson

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  • ·Ability of using different dry powder inhalers during COPD exacerbations

    Page :211-216

    Andriana I. Papaioannou, Yiolanda Herodotou, Ioannis Tomos, Vasiliki Apollonatou, Galateia Verykokou, Evgenia Papathanasiou, Effrosyni D. Manali, Stelios Loukides, Spyros A. Papiris

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  • ·Aerosol delivery during spontaneous breathing with different types of nebulizers- in vitro/ex vivo models evaluation

    Page :225-231

    Hui-Ling Lin, Tien-Pei Fang, Hui-Sun Cho, Gwo-Hwa Wan, Meng-Jer Hsieh, James B. Fink

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