Our modern society has to face several health problems, among which climate change characterized by global warming and increased pollution and obesity epidemic and associated morbidities are prominent ones. Interestingly, several epidemiological studies argue for a closed connection between these two health concerns, in fact pointing out a bidirectional relationship. Global warming and its associated exposure to pollutants could contribute to weight gain through different mechanisms, including some endocrine disorders linked to adipocyte dysfunction (adiposopathy) and reduced thermogenesis, as well as a reluctance to physical activity in a hot ambient temperature. Conversely, obesity epidemic may play a role in global warming by an increased consumption of energetic ultra-processed foods and an enhanced energy waste for transportation, both leading to increased greenhouse gas emission. Thus, there is an urgent need for greater action to slow the process of global warming also to prevent harmful effects on health linked to obesity epidemic.