ENDOCAN-TUTHYREF guidelines. Locoregional therapies for locally advanced and/or metastatic thyroid cancer - 28/06/25

Doi : 10.1016/j.ando.2025.101790

Arnaud Jannin ^a,^⁎ , Alexandre Escande ^b, Dana Hartl ^c, Guillaume Louvel ^d, Ingrid Breuskin ^c, Françoise Borson-Chazot ^e, Julien Hadoux ^f, Livia Lamartina ^f, Christine Do Cao ^a, Frédéric Deschamps ^g,^h
^a Department of Endocrinology, CHRU de Lille, Hôpital Claude-Huriez, Lille, France
^b Radiotherapy Department, Centre Léonard-de-Vinci, Dechy, France
^c Thyroid Surgery Unit, Department of Otorhinolaryngology-Head and Neck Surgery, Institute Gustave-Roussy, Paris, France
^d Department of Radiotherapy, Gustave-Roussy Cancer Campus, Paris-Saclay University, Villejuif, France
^e Department of Endocrinology, Hôpital Louis-Pradel, Hospices Civils de Lyon, Lyon, France
^f Department of Nuclear Medicine and Endocrine Oncology, Gustave-Roussy, Paris, France
^g Department of Interventional Radiology, Gustave-Roussy, Université Paris-Saclay, 114, rue Édouard-Vaillant, 94805 Villejuif, France
^h Université Paris-Saclay, CNRS, Gustave-Roussy, Aspects Métaboliques et Systémiques de l’Oncogenèse pour de Nouvelles Approches Thérapeutiques, 94805 Villejuif, France

^⁎Corresponding author. Service d’Endocrinologie, Diabétologie, Oncologie Endocrinienne et Métabolisme, Hôpital Claude-Huriez, CHU de Lille, 59037 Lille cedex, France.Service d’Endocrinologie, Diabétologie, Oncologie Endocrinienne et Métabolisme, Hôpital Claude-Huriez, CHU de LilleLille cedex59037France

Abstract

This article presents consensus recommendations by a multidisciplinary panel of endocrinologists, medical oncologists, pathologists, radiation oncologists, surgeons and nuclear medicine physicians. The recommendations specifically address iodine-refractory well-differentiated thyroid carcinoma and locally advanced and/or metastatic medullary thyroid carcinoma. Treatment algorithms based on risk–benefit assessments of various multimodal therapeutic approaches are proposed for each clinical scenario. Given the limited data available on the management of these rare but aggressive forms of thyroid cancer, these consensus recommendations provide essential guidance for multidisciplinary teams to ensure optimal care for patients with these complex thyroid carcinomas.

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Keywords : Thyroid carcinoma, Locoregional therapy, Surgery, Radiotherapy, Stereotactic ablative radiotherapy, Thermoablation, Cryoablation, Radiofrequency ablation, Metastasis