Heart rate variability analysis is more sensitive at identifying neonatal sepsis than conventional vital signs - 16/09/15
Abstract |
Background |
Sepsis remains the largest preventable source of neonatal mortality in the world. Heart rate variability (HRV) analysis and noninvasive cardiac output have been shown to be useful adjuncts to sepsis detection in many patient groups.
Methods |
With Institutional Review Board approval, 4 septic and 6 nonseptic extremely low birth weight patients were enrolled. Data from septic and healthy patients were collected for 5 hours. Electrocardiogram waveform and traditional vital signs were collected and the RR intervals were calculated; then HRV analysis was performed in both the time and frequency domain.
Results |
HRV measurements in time domain, heart rate, and pulse oximetry (SpO2) were significantly different in septic patients vs nonseptic controls.
Conclusions |
These results indicate that nonconventional vital signs such as HRV are more sensitive than traditionally used vital signs, such as cardiac output and mean arterial pressure, in the confirmation of sepsis in extremely low birth weight neonates. HRV may allow for earlier identification of septic physiology.
Le texte complet de cet article est disponible en PDF.Keywords : Heart rate variability, Sepsis, Neonatal, Noninvasive vital signs
Plan
| This work was supported by grants T32-GM8256 (F.J.B.) from the National Institutes of Health, Office of Naval ResearchN00014-12-C-0556, U.S. ArmyW23RYX0104N605000, and the U.S. Army Medical Research Materiel Command under Award No. W81XWH-14-2-0161. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. |
|
| The authors declare no conflicts of interest. |
Vol 210 - N° 4
P. 661-667 - octobre 2015 Retour au numéro
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