Noninvasive nucleic acid–based approaches to monitor placental health and predict pregnancy-related complications - 01/10/15
Abstract |
During pregnancy, the placenta releases a variety of nucleic acids (including deoxyribonucleic acid, messenger ribonucleic acid, or microribonucleic acids) either as a result of cell turnover or as an active messaging system between the placenta and cells in the maternal body. The profile of released nucleic acids changes with the gestational age and has been associated with maternal and fetal parameters. It also can directly reflect pathological changes in the placenta. Nucleic acids may therefore provide a rich source of novel biomarkers for the prediction of pregnancy complications. However, their utility in the clinical setting depends, first, on overcoming some technical considerations in their quantification, and, second, on developing a better understanding of the factors that influence their function and abundance.
Le texte complet de cet article est disponible en PDF.Key words : cell-free deoxyribonucleic acid, cell-free messenger ribonucleic acid, microribonucleic acid, pregnancy complications, screening
Plan
| The funding sources had no involvement in review preparation and in the decision to submit the article for publication. |
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| This work was supported by grant 49520 from the Canadian Institutes of Health Research (W.P.R.). |
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| The authors report no conflict of interest. |
Vol 213 - N° 4S
P. S197-S206 - octobre 2015 Retour au numéro
Article précédent
- Epigenetic regulation of human placental function and pregnancy outcome: considerations for causal inference
- Vania Januar, Gernot Desoye, Boris Novakovic, Silvija Cvitic, Richard Saffery
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