Does active smoking induce hematogenous metastatic spread in colon cancer? - 15/10/15
Abstract |
Background |
No consensus exists on the influence of active smoking on the baseline staging of colon cancer patients.
Methods |
A cohort of colon cancer patients treated surgically at Massachusetts General Hospital (2004 to 2011) was reviewed.
Results |
Of 1,071 patients, 563 reported ever smoking, among which 128 (12%) patients were current smokers. Ex-smokers and never smokers had similar rates of nodal (relative risk [RR] .9, P = .19) and metastatic disease (RR .96, P = .72), leading to comparable colon cancer–related mortality (RR 1.01, P = .95). Current smokers had similar rates of lymph node disease (RR 1.01, P = .88), but had significantly higher stage-adjusted odds of metastatic disease at presentation (odds ratio 2.57, 95% confidence interval 1.36 to 4.98, P = .005), in addition to higher stage-adjusted all-cause mortality (hazard ratio 1.44, P = .017).
Conclusions |
Active smoking was a stage-independent risk factor for baseline hematogenous metastasis and mortality. As this link was not present in former smokers, a potential healthcare benefit may be achieved in terms of baseline colon cancer presentation and outcomes through smoking cessation.
Le texte complet de cet article est disponible en PDF.Highlights |
• | No consensus exists on the influence of active smoking on colon cancer staging. |
• | Surgical colon cancer patient cohort at Massachusetts General Hospital (2004–2011). |
• | Current smokers had stage-independent links with baseline hematogenous metastasis. |
• | Active smoking also had a stage-independent association with mortality. |
• | Risks were not present in former smokers: new potential benefit of smoking cessation. |
Keywords : Colon cancer, Current smoking, Active smoking, Baseline metastasis, Hematogenous metastasis, Mortality
| The authors declare no conflicts of interest. |
Vol 210 - N° 5
P. 930-932 - novembre 2015 Retour au numéro
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