Relationship Between Mean Platelet Volume and Pulmonary Embolism in Patients With Deep Vein Thrombosis - 20/10/15
, Fatih Aksoy, MD b, Yasin Turker, MD b, Bayram Ali Uysal, MD b, Mehmet Fatih Alpay, MD c, Abdullah Dogan, MD b, Gökay Nar, MD a, Ercan Varol, MD bRésumé |
Background |
Mean platelet volume (MPV) has been demonstrated to be associated with deep vein thrombosis (DVT). However, its role in the prediction of pulmonary embolism (PE), which is a major complication of DVT, is still unclear. Therefore, we investigated the association of MPV values with acute PE in patients with DVT.
Method |
The study included three groups: patients with DVT and PE (n=98); patients with DVT without PE (n=97); and control group (No DVT, No PE, n=98). We also evaluated DVT patients according to the MPV values on admission and categorised them into two groups: MPV≤9.15 fL (n=82) and MPV>9.15 fL (n=113).
Results |
MPV was significantly higher in all DVT patients than controls (9.3±0.9 fL vs 7.9±0.7 fL, p<0.001) and in DVT patients with PE than DVT patients without PE (9.9±0.6 fL vs 8.7±0.7 fL, p<0.001). The rate of PE was higher in patients with DVT with MPV>9.15 fL than those with MVP≤9.15 fL (75.2% vs 15.9%, p<0.001). The presence of PE in patients with DVT was independently associated with MPV (OR: 22.19, 95%CI: 9.39–53.19, P<0.001).
Conclusion |
Although our findings should be considered within the limitations of the study, they suggest that MPV measures may be elevated in DVT patients and a higher MPV may be associated with PE in patients with DVT.
Le texte complet de cet article est disponible en PDF.Keywords : Mean platelet volume, Platelet activation, Platelet count, Deep vein thrombosis, Acute pulmonary embolism
Plan
Vol 24 - N° 11
P. 1081-1086 - novembre 2015 Retour au numéro
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