Insulin-like growth factor binding proteins 4-6 - 30/10/15
: Deputy Director, Professor of MedicineAbstract |
Insulin-like growth factor binding proteins (IGFBPs) 4-6 have important roles as modulators of IGF actions. IGFBP-4 and IGFBP-6 predominantly inhibit IGF actions, whereas IGFBP-5 may enhance these actions under some circumstances. IGFBP-6 is unique among the IGFBPs for its marked IGF-II binding preference. IGFBPs 4-6 are found in the circulation as binary complexes with IGFs that can enter tissues. Additionally, about half of the circulating IGFBP-5 is found in ternary complexes with IGFs and an acid labile subunit; this high molecular complex cannot leave the circulation and acts as an IGF reservoir. IGFBPs 4-6 also have IGF-independent actions. These IGFBPs are regulated in a cell-specific manner and their dysregulation may play a role in a range of diseases including cancer. However, there is no clear clinical indication for measuring serum levels of these IGFBPs at present.
Le texte complet de cet article est disponible en PDF.Keywords : insulin-like growth factor, binding protein, protein structure, regulation, cellular action
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Vol 29 - N° 5
P. 713-722 - octobre 2015 Retour au numéro
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- Insulin-like growth factor binding-protein-3 (IGFBP–3)
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