Fish and polyunsaturated fat intake and development of allergic and nonallergic rhinitis - 06/11/15
, Inger Kull, PhD a, b, c, Marit Westman, MD d, e, Niclas Håkansson, PhD a, Alicja Wolk, Dr Med Sci a, Erik Melén, MD, PhD a, c, Magnus Wickman, MD, PhD a, c, Anna Bergström, PhD aAbstract |
Background |
Rhinitis is one of the most common diseases in childhood. Fish, polyunsaturated fatty acid (PUFA), and vitamin D intakes have been hypothesized to affect the risk of allergic disease; however, it is unclear whether these are linked to the development of rhinitis.
Objective |
We sought to assess potential associations between consumption of fish, dietary n-3 and n-6 PUFAs, and vitamin D at age 8 years and development of allergic rhinitis (AR) and nonallergic rhinitis (NAR) between the ages of 8 and 16 years.
Methods |
We included 1970 participants from a birth cohort. Data on dietary intake was obtained from a food frequency questionnaire at age 8 years. The rhinitis definition was based on questionnaires and IgE measures.
Results |
The prevalence of rhinitis symptoms at age 8 years was 19% (n = 380). Among the 1590 children without rhinitis symptoms at age 8 years, 21% (n = 337) had AR between ages 8 and 16 years, and 15% (n = 236) had NAR. Regular intake of oily fish and higher long-chain n-3 PUFA intake were associated with a reduced risk of cumulative incidence of NAR (adjusted odds ratio, 0.52 [95% CI, 0.32-0.87] for oily fish; odds ratio, 0.45 [95% CI, 0.30-0.67] for highest vs lowest tertile of long-chain n-3 PUFAs; P trend < .001). The results for rhinitis, irrespective of AR and NAR, were in line with the findings for NAR.
Conclusion |
Regular consumption of oily fish and dietary long-chain n-3 PUFAs in childhood might decrease the risk of rhinitis, especially NAR, between the ages of 8 and 16 years.
Le texte complet de cet article est disponible en PDF.Key words : Adolescent, allergic rhinitis, BAMSE, children, diet, fatty acid, fish, nonallergic rhinitis, prospective studies, vitamin D
Abbreviations used : AA, ALA, AR, BAMSE, FFQ, LA, NAR, OR, PUFA
Plan
| Supported by the Stockholm County Council; the Swedish Research Council; the Swedish Research Council Formas; the Swedish Heart-Lung Foundation; the Swedish Asthma and Allergy Association; the Swedish Research Council for Health, Working Life and Welfare; and the European Commission's Seventh Framework 29 Program MeDALL (grant agreement no. 261357). Thermo Fisher Scientific kindly provided the reagents. The funding sources had no active role in the conducted research. |
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| Disclosure of potential conflict of interest: J. Magnusson and A. Bergström have received research support from the Swedish Research Council Formas and the Swedish Research Council. M. Westman has received payment for manuscript preparation from MEDA. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 136 - N° 5
P. 1247 - novembre 2015 Retour au numéro
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