Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes - 24/11/15

Doi : 10.1016/j.jpeds.2015.07.006

Michael von Rhein, MD ^1,^2,³, Andreas Buchmann, PhD ⁴, Cornelia Hagmann, MD, PhD ⁵, Hitendu Dave, MD ⁶, Vera Bernet, MD ^3,⁷, Ianina Scheer, MD ⁸, Walter Knirsch, MD ^3,^9,^{^{∗
Contributed equally.}}, Beatrice Latal, MD, MPH ^1,^3,^{^{∗
Contributed equally.}}
on behalf of the
Heart and Brain Research Group^{^†}
List of members of the Heart and Brain Research Group is available at www.jpeds.com (Appendix).
Vera Bernet, MD, Christoph Bürki, MD, Hitendu Dave, MD, René Prêtre, MD, Cornelia Hagmann, MD, PhD, Walter Knirsch, MD, Oliver Kretschmar, MD, Christian Kellenberger, MD, Ianina Scheer, MD, Beatrice Latal, MD, MPH, Rabia Liamlahi, MD, Michael von Rhein, MD, Barbara R. Plecko, MD, Felix H. Sennhauser, MD

¹ Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland
² Developmental Pediatrics, SPZ, Kantonsspital Winterthur, Winterthur, Switzerland
³ Children's Research Center, University Children's Hospital, Zurich, Switzerland
⁴ Department of Neurology, University Hospital Zurich, Zurich, Switzerland
⁵ Department of Neonatology, University Hospital Zurich, Zurich, Switzerland
⁶ Congenital Cardiovascular Surgery, University Children's Hospital Zurich, Zurich, Switzerland
⁷ Department of Neonatology and Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland
⁸ Diagnostic Imaging, University Children's Hospital, Zurich, Switzerland
⁹ Cardiology, University Children's Hospital, Zurich, Switzerland

Abstract

Objectives

To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.

Study design

Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.

Results

Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).

Conclusions

Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.

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Keyword : CHD, MRI

Plan

Supported by Swiss Heart Foundation, Else Kröner-Fresenius-Stiftung. C.H. was supported by the Swiss National Foundation (PMPDP3_129104). The authors declare no conflicts of interest.

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Vol 167 - N° 6

P. 1259 - décembre 2015 Retour au numéro

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Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes - 24/11/15

Abstract

Objectives

Study design

Results

Conclusions

Plan

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