Quantitative Dobutamine Stress Echocardiography Using Speckle-Tracking Analysis versus Conventional Visual Analysis for Detection of Significant Coronary Artery Disease after ST-Segment Elevation Myocardial Infarction - 03/12/15
Abstract |
Background |
Residual ischemia detection after ST-segment elevation myocardial infarction (STEMI) during dobutamine stress echocardiography (DSE) using visual analysis is challenging. The aim of the present study was to investigate the feasibility and accuracy of two-dimensional speckle-tracking strain DSE to detect significant coronary artery disease (CAD) after STEMI.
Methods |
First STEMI patients (n = 105; mean age, 60 ± 11 years; 86% men) treated with primary percutaneous coronary intervention undergoing full-protocol DSE at 3 months and repeat coronary angiography within 1 year were retrospectively included. Using two-dimensional speckle-tracking echocardiography, segmental and global left ventricular peak longitudinal systolic strain (PLSS) at rest and peak stress and change (Δ) in PLSS were measured. Significant CAD was defined as detection of >70% diameter stenosis at coronary angiography.
Results |
In total, 1,653 (93%) and 1,645 (92%) segments were analyzable at rest and peak stress, respectively. At follow-up, 38 patients (36%) showed significant angiographic CAD. These patients demonstrated greater worsening in global PLSS from rest to peak (−16.8 ± 0.5% to −12.6 ± 0.5%) compared with patients without significant CAD (−16.6 ± 0.4% to −14.3 ± 0.3%; group-stage interaction P < .001). The optimal cutoff of ΔPLSS for the detection of significant CAD on receiver operating characteristic curve analysis was ≥1.9% (area under the curve, 0.70; sensitivity, 87%; specificity, 46%; accuracy, 60%). Using a sentinel segment approach (apex, midposterior, and midinferior for the left anterior descending, left circumflex, and right coronary artery territories, respectively), larger segmental ΔPLSS was also independently associated with significant CAD (odds ratio, 1.1; 95% CI, 1.1–1.2).
Conclusions |
Two-dimensional speckle-tracking echocardiographic strain analysis is feasible on DSE after STEMI and represents a promising new technique to detect significant angiographic CAD at follow-up.
Le texte complet de cet article est disponible en PDF.Keywords : ST-segment elevation myocardial infarction, Coronary angiography, Dobutamine stress echocardiography, Two-dimensional strain
Abbreviations : AUC, CAD, DSE, IRA, LAD, LCx, LV, OR, PLSS, PSI, PSS, RCA, ROC, STE, STEMI, 2D, WMS, WMSI
Plan
| Dr Joyce and Ms Hoogslag contributed equally to this work and share first authorship. |
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| Dr Joyce was supported during the period of this research by a European Society of Cardiology Training Grant and an Irish national educational bursary sponsored by Merck, Sharp & Dohme. Ms Hoogslag received a PhD grant provided by the Leiden University Medical Center. Dr Debonnaire was supported by a Sadra Medical Research Grant (Boston Scientific). |
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| The Department of Cardiology at Leiden University Medical Center receives unrestricted grants from Biotronik (Berlin, Germany), Boston Scientific (Natick, MA), GE Healthcare (Buckinghamshire, United Kingdom), and Medtronic (Minneapolis, MN). Dr Delgado received consulting fees from Medtronic and St. Jude Medical (St. Paul, MN). |
Vol 28 - N° 12
P. 1379 - décembre 2015 Retour au numéro
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