Use of quantitative susceptibility mapping (QSM) in progressive multifocal leukoencephalopathy - 03/02/16
, N. Menjot de Champfleur b, c, 1, J. Deverdun b, c, X. Ayrignac a, E. Nerrant a, A. Makinson d, M.L. Casanova d, P. Labauge aBienvenue sur EM-consulte, la référence des professionnels de santé.
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| Iconographies | 4 |
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Summary |
Background |
Progressive multifocal leukoencephalopathy (PML) is an opportunistic demyelinating encephalopathy related to JC virus. Its characteristics on conventional brain MRI are well known and are important for the diagnosis.
Objective |
To analyze SWI hypointensities recently described in U-fibers and cortex adjacent to the white matter lesions of PML.
Methods |
Prospective study including four patients with an history of definite diagnosis of PML. Clinical data were collected retrospectively. Brain MRI exams were done on a 3T magnet, including FLAIR, T2 GRE sequences and SWI.
Results |
Four males were included (mean age: 47 years, mean PML duration: 24.2 months). Immunosuppression was related to AIDS (n=2), natalizumab for multiple sclerosis (n=1), B-cell lymphoma treated by chemotherapeutic agents and rituximab (n=1). All patients had SWI hypointensities in cortex and/or U-fibers adjacent to the white matter lesions. QSM always suggested a paramagnetic effect.
Conclusion |
SWI and T2 GRE hypointensities in cortex and U-fibers adjacent to the white matter lesions seem highly prevalent in PML, irrespective of the delay between PML onset and the MRI. QSM data suggest a paramagnetic effect.
Le texte complet de cet article est disponible en PDF.Keywords : HIV infection, Magnetic resonance imaging, Multiple sclerosis, Progressive multifocal leukoencephalopathy
Abbreviations : AIDS, JCV, GRE, PML, QSM, SWI
Plan
Vol 43 - N° 1
P. 6-10 - février 2016 Retour au numéro
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