Bipolar Depression and Cognitive Impairment : Shared Mechanisms and New Treatment Avenues - 13/02/16

Doi : 10.1016/j.psc.2015.09.004

Colin A. Depp, PhD ^a,^b,^⁎ , Sheena Dev, BS ^a,^c,^{^{1
Present address: 3350 La Jolla Village Drive, VMRF Building 13, San Diego, CA 92161.}}, Lisa T. Eyler, PhD ^a,^b,^{^{1
Present address: 3350 La Jolla Village Drive, VMRF Building 13, San Diego, CA 92161.}}
^a Department of Psychiatry, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
^b Desert-Pacific Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
^c SDSU-UCSD Joint Doctoral Program, Clinical Psychology, San Diego, CA, USA

^∗Corresponding author. UC San Diego, 9500 Gilman Drive (0664), La Jolla, CA 92093-0664.

Résumé

Depression and cognitive impairment are pervasive and highly disabling aspects of bipolar disorder. Although cognitive impairment is partially independent from mood episodes, depressive symptoms may increase the risk of cognitive impairment in bipolar disorder through inflammatory processes as well as health risks such as obesity and sedentary behavior. Novel treatment avenues at the intersection of bipolar depression and cognitive impairment target inflammation directly or indirectly health behaviors such as diet, physical activity, and sleep hygiene.

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Keywords : Neuropsychology, Mood disorders, Aging, Brain function, Health behavior

Plan

Key points

Introduction

Prevalence and distribution of cognitive impairments in euthymic patients

Comparison of cognitive deficits in bipolar disorder with those in other psychiatric illnesses

Studies of the shorter-term effect of bipolar depression on cognitive function

Studies of the long-term effect of bipolar depression on cognitive function

Impact of cognitive impairment and depression on psychosocial functioning

Potential pathways between depression and cognitive impairment

Evidence for a Direct Pathway from Bipolar Depression to Cognitive Impairment

Evidence for an Indirect Pathway from Bipolar Depression to Health Risks to Cognitive Impairment

Psychosocial Disabilities May Reciprocally Increase Depression and Cognitive Impairment

Interventions to remediate cognitive impairment in bipolar depression

Pharmacologic Treatments

Cognitive Training and Remediation

Physical Activity and Weight Loss Interventions

Treatment of Insomnia

Compensating for Cognitive Impairment in Learning-Based Therapies

Summary

	Disclosures: None of the authors has any conflicts of interests to report.
	Role of the Funding Source: The study was funded in part by the National Institute of Mental Health Grants MH100417 and MH100318.

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Vol 39 - N° 1

P. 95-109 - mars 2016 Retour au numéro

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Bipolar Depression and Cognitive Impairment : Shared Mechanisms and New Treatment Avenues - 13/02/16

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