Familial Hypercholesterolemia - 17/02/16
Résumé |
Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substantial reduction of cardiovascular events and death in patients with familial hypercholesterolemia. It is important to increase awareness of this disorder in physicians and patients to reduce the burden of this disorder.
Le texte complet de cet article est disponible en PDF.Keywords : Familial hypercholesterolemia, Statins, Ezetimibe, Bile acid sequestrants, LDL apheresis, Lomitapide, Mipomersen
Plan
| This article originally appeared in Cardiology Clinics, Volume 33, Issue 2, May 2015. |
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| Conflict of Interest Statement: Dr V.E. Bouhairie receives support from Award Number T32DK007120 from the National Institute of Diabetes and Digestive and Kidney Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health; Dr A.C. Goldberg: Research Support: Research contracts to institution— Merck, Genzyme/ISIS/Sanofi-Aventis, GlaxoSmithKline, Amgen, Amarin, Regeneron/Sanofi-Aventis, Roche/Genentech, Pfizer; Consulting: Tekmira, Astra-Zeneca, uniQure; Editorial: Merck Manual. |
Vol 45 - N° 1
P. 1-16 - mars 2016 Retour au numéro
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- Erratum
- New Cholesterol Guidelines for the Management of Atherosclerotic Cardiovascular Disease Risk : A Comparison of the 2013 American College of Cardiology/American Heart Association Cholesterol Guidelines with the 2014 National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia
- Bhavin B. Adhyaru, Terry A. Jacobson
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