Lipoprotein Apheresis - 17/02/16
, Linda Hemphill, MD bRésumé |
Patients with familial hypercholesterolemia (FH) have early development of atherosclerosis and cardiovascular disease (CVD). Lipid level–lowering medications are not always successful in reducing increased low-density lipoprotein C (LDL-C) levels. Lipoprotein apheresis (LA) therapy has proven its clinical benefit in reducing CVD events for patients with FH with hypercholesterolemia. LA reduces LDL-C levels by more than 60% in patients with FH and reduces CVD events. LA also reduces Lp(a) levels and CVD events. LA reduces inflammatory markers and blood viscosity.
Le texte complet de cet article est disponible en PDF.Keywords : Lipoprotein apheresis, Familial hypercholesterolemia, LDL-C, CVD, Atherosclerosis, Lp(a)
Plan
| This article originally appeared in Cardiology Clinics, Volume 33, Issue 2, May 2015. |
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| Disclosures: Dr P.M. Moriarty, Research for Amgen, Kowa, Lilly, Novartis, Sanofi, Regeneron, Genzyme, Pfizer, Catabasis, Espirion, B. Braun, and Kaneka; Consultant for Regeneron, Duke Clinical research Institute, Lilly, Catabasis, B Braun, Kaneka, and Genzyme; Honoraria from Esperion. |
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| Dr L. Hemphill, Research: Regeneron, Sanofi and ISIS. |
Vol 45 - N° 1
P. 39-54 - mars 2016 Retour au numéro
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