Changes in Fasting Lipids during Puberty - 25/02/16
, Nicole L. Mihalopoulos, MD, MPH 2, Richard Holubkov, PhD 2, Shifan Dai, MD, PhD 3, Darwin R. Labarthe, MD, MPH, PhD 4Abstract |
Objective |
To describe longitudinal changes in plasma lipid levels and pubertal stage in youths from age 8-18 years, in Project HeartBeat!
Study design |
Fasting blood samples and pubertal stage, using physical assessment of secondary sex characteristics, were obtained every 4 months for up to 4 years in a mixed longitudinal study of 633 children (49.1% female, 20.1% black), initially aged 8, 11, and 14 years. Total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, triglycerides (TG), and nonhigh density lipoprotein-cholesterol measurements were obtained. Data were collected from 1991-1995.
Results |
Pubertal stage correlations with age varied among all race-sex groups (range, r = 0.61-0.70), and a given pubertal stage could represent a range of 5 years or more of chronological age. Throughout puberty, levels of total cholesterol, low density lipoprotein-cholesterol, and nonhigh density lipoprotein-cholesterol decreased, TG in males increased, and high density lipoprotein-cholesterol and TG in females showed no changes. Within a given pubertal stage, plasma lipid levels tended to differ by race, sex, or both.
Conclusions |
Lipid levels change markedly by pubertal stage, and patterns differ by sex and race. Chronological age ranges widely within a given pubertal stage and is an insensitive indicator of pubertal stage and the related changes in lipid levels. Pubertal development should be considered when determining screening criteria to identify youths with adverse blood lipid levels.
Le texte complet de cet article est disponible en PDF.Keyword : BMI, HDL-C, LDL-C, non-HDL-C, TC, TG
Plan
| Supported by the National Heart, Lung, and Blood Institute (through Cooperative Agreement U01-HL-41166) and the Centers for Disease Control and Prevention through the Southwest Center for prevention Research (U48/CCU609653). N.M. was supported by the National Heart, Lung, and Blood Institute (HL#092069). The authors declare no conflicts of interest. |
Vol 170
P. 199-205 - mars 2016 Retour au numéro
Article précédent
- Left Ventricular Mass Indexing in Infants, Children, and Adolescents: A Simplified Approach for the Identification of Left Ventricular Hypertrophy in Clinical Practice
- Marcello Chinali, Francesco Emma, Claudia Esposito, Gabriele Rinelli, Alessio Franceschini, Anke Doyon, Francesca Raimondi, Giacomo Pongiglione, Franz Schaefer, Maria Chiara Matteucci
- The Effect of Parental Involvement on Children's Physical Activity
- Michael J. Rebold, Andrew Lepp, Mallory S. Kobak, John McDaniel, Jacob E. Barkley
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?