MR Imaging–Guided Partial Volume Correction of PET Data in PET/MR Imaging - 06/03/16

Doi : 10.1016/j.cpet.2015.09.002

Kjell Erlandsson, PhD ^a,^⁎ , John Dickson, PhD ^b, Simon Arridge, PhD ^c, David Atkinson, PhD ^d, Sebastien Ourselin, PhD ^e, Brian F. Hutton, PhD ^a,^f
^a Institute of Nuclear Medicine, University College London, UCLH, Euston Road (T-5), London NW1 2BU, UK
^b Institute of Nuclear Medicine, University College London Hospital, UCLH, Euston Road (T-5), London NW1 2BU, UK
^c Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK
^d Centre for Medical Imaging, University College London, 250 Euston Road, London NW1 2PG, UK
^e Centre for Medical Imaging Computing, University College London, Gower Street, London WC1E 6BT, UK
^f The Centre for Medical Radiation Physics, University of Wollongong, Northfields Avenue, Wollongong NSW 2522, Australia

^∗Corresponding author. UCLH, Euston Road (T-5), London NW1 2BU, UK.

Résumé

Partial volume effects are caused by the limited spatial resolution of the PET system. There is increasing evidence that partial volume correction (PVC) is necessary to guarantee quantitative accuracy in PET; however, there is reluctance to apply PVC routinely in clinical practice, partly because of uncertainty regarding the method of choice. To perform accurate PVC, it is necessary to introduce information from high-resolution anatomic images, such as MR imaging. All the methods rely on accurate coregistration between the anatomic image and the PET image. PET/MR imaging offers clear advantages for PVC and can help alleviate the image registration issues.

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Keywords : Partial volume effects, Partial volume correction, PET/MR imaging, Quantification

Plan

Key points

Introduction

Partial volume correction methods

Postreconstruction Methods

Reconstruction-Based Methods

Clinical applications of partial volume correction

The authors have nothing to disclose.

The amyloid and fludeoxyglucose PET images shown were from a study supported by AVID Radiopharmaceuticals (a wholly owned subsidiary of Eli Lilly) and the National Brain Appeal, Frontotemporal Dementia Research Fund. This work was supported by the EPSRC (grant number EP/K005278/1), the EC under the FP7 INSERT project (grant number 305311), and the National Institute for Health Research University College London Hospitals Biomedical Research Center.

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Vol 11 - N° 2

P. 161-177 - avril 2016 Retour au numéro

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MR Imaging–Guided Partial Volume Correction of PET Data in PET/MR Imaging - 06/03/16

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