Anemia frequently accompanies and plays a minor role in the presentation and course of infection, whether parasitic, bacterial, or viral. However, a variety of infections, many of which are common in Africa and Asia, cause specific hematologic syndromes. The pathophysiology of these syndromes is complex, and to some extent, reduced red cell production may form part of an innate protective host response to infection. Across the world and in endemic areas, malaria is the most important among this group of infections and forms a major part of everyday practice.