Decreased interhemispheric functional coordination underlying the cognitive impairment in late-onset depression - 13/04/16
Résumé |
Background |
The intuitive association between cognitive dysfunction in late onset depression (LOD) and the aberrant functional activity in the brain's default-mode network (DMN) has prompted interest in exploring the role of the DMN in LOD. The altered pattern of resting state voxel-mirrored homotopic connectivity (VMHC) in cognitive processes is not yet well understood in LOD.
Methods |
The study was designed to examine the implicit coupling between the alteration of interhemispheric functional coordination and cognitive impairment in LOD. Thirty-one LOD patients and 37 matched healthy controls (HC) underwent neuropsychological tests and functional magnetic resonance imaging (fMRI) in this study.
Results |
Compared to HC group, attenuated VMHC in superior frontal gyrus, superior temporal gyrus, posterior cerebellar lobe, postcentral and precentral gyrus was observed in LOD. Neuro-behavioral relevancy approach revealed that the imbalanced interhemispheric functional coordination in bilateral cerebellum was positively correlated with the performance of trail making test in LOD (r=0.367, P=0.040).
Conclusion |
Altered linkage pattern of intrinsic homotopic connectivity and cognition was firstly investigated in LOD, and it would provide a novel clue to reveal the neural substrates underlying the cognitive dysfunction in LOD.
Le texte complet de cet article est disponible en PDF.Keywords : Late-onset depression, Voxel-mirrored homotopic connectivity, Functional magnetic resonance imaging, Cognitive function, Cerebellum
Plan
Vol 33 - N° S
P. S197 - mars 2016 Retour au numéro
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