Extremely Preterm-Born Infants Demonstrate Different Facial Recognition Processes at 6-10 Months of Corrected Age - 25/04/16
Abstract |
Objectives |
To compare cortical hemodynamic responses to known and unknown facial stimuli between infants born extremely preterm and term-born infants, and to correlate the responses of the extremely preterm-born infants to regional cortical volumes at term-equivalent age.
Study design |
We compared 27 infants born extremely preterm (<28 gestational weeks) with 26 term-born infants. Corrected age and chronological age at testing were between 6 and 10 months, respectively. Both groups were exposed to a gray background, their mother's face, and an unknown face. Cerebral regional concentrations of oxygenated and deoxygenated hemoglobin were measured with near-infrared spectroscopy. In the preterm group, we also performed structural brain magnetic resonance imaging and correlated regional cortical volumes to hemodynamic responses.
Results |
The preterm-born infants demonstrated different cortical face recognition processes than the term-born infants. They had a significantly smaller hemodynamic response in the right frontotemporal areas while watching their mother's face (0.13 μmol/L vs 0.63 μmol/L; P < .001). We also found a negative correlation between the magnitude of the oxygenated hemoglobin increase in the right frontotemporal cortex and regional gray matter volume in the left fusiform gyrus and amygdala (voxels, 25; r = 0.86; P < .005).
Conclusion |
At 6-10 months corrected age, the preterm-born infants demonstrated a different pattern in the maturation of their cortical face recognition process compared with term-born infants.
Le texte complet de cet article est disponible en PDF.Abbreviations : HbO2, HHb, IVH, MRI, NIRS, PVL, TEA
Plan
| Supported by Stiftelsen Samariten, Sällskapet barnavård, Drottning Silvias Jubileums Foundation, the Swedish Medical Research Council (523-2011-3981), the regional agreement on medical training and clinical research between Stockholm County Council and the Karolinska Institutet (ALF-20140316), the Marianne and Marcus Wallenberg Foundation (2011.0085), the Swedish Order of Freemasons in Stockholm, European Union 7th programme (EC-GA 260908), and the Swedish Brain Foundation (FP2014-0135). The authors declare no conflicts of interest. |
Vol 172
P. 96 - mai 2016 Retour au numéro
Article précédent
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