Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma - 05/05/16
Doi : 10.1016/j.jaci.2015.10.013
Thomas Colley, PhD a, Nicolas Mercado, PhD a, Yuichi Kunori, PhD a, Christopher Brightling, FRCP b, Pankaj K. Bhavsar, PhD a, Peter J. Barnes, FRS a, Kazuhiro Ito, PhD a 
a Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
b Respiratory Medicine, Glenfield Hospital, University of Leicester, Leicester, United Kingdom
| T.C. was funded by Asthma UK (06/010), London, United Kingdom. P.J.B. and K.I. received grants from Asthma UK (06/010) for this work. C.B. was funded as a Wellcome Senior Fellow and supported by the Leicester Respiratory National Institute for Health Research (NIHR) Biomedical Research Unit. This article presents independent research funded by the NIHR. The views expressed are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health. The funding sources played no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. |
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| Disclosure of potential conflict of interest: T. Colley has received a grant from Asthma UK (06/010) and is employed by Pulmocide. C. Brightling has consultant arrangements with GlaxoSmithKline, AstraZeneca, Novartis, Chiesi, Boehringer Ingelheim, and Roche and has received grants from GlaxoSmithKline, AstraZeneca, Chiesi, Boehringer Ingelheim, Novartis, and Roche. P. J. Barnes has received grants from Asthma UK (grant no. 06/010), Takeda, Chiesi, and Pfizer and has received payment for lectures from Chiesi and Boehringer Ingelheim. K. Ito has received a grant from Asthma UK (grant no. 06/010) and is employed by Pulmocide. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2016
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 137 - N° 5
P. 1595 - mai 2016 Retour au numéro
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