Fungal infections constitute a diverse spectrum of infections with variable clinical and imaging features. They are commonly opportunistic infections that affect immunocompromised individuals secondary to inherited or acquired disorders. Fungal infections may affect multiple organ systems and contribute to significant morbidity and mortality. Although the imaging features of some fungal infections are characteristic and permit their diagnosis, many mycotic infections manifest nonspecific findings. Definitive diagnosis often depends on histopathological analysis. Early diagnosis requires both clinical suspicion and supporting radiological evidence. Early treatment results in reduced morbidity and mortality. This article reviews the imaging findings in opportunistic and endemic fungal infections.