Shift Work: A Risk Factor for Central Serous Chorioretinopathy - 14/05/16

Doi : 10.1016/j.ajo.2016.02.012

Elodie Bousquet ^a,^c,^⁎ , Myriam Dhundass ^a, Mathieu Lehmann ^a, Pierre-Raphaël Rothschild ^a,^c, Virginie Bayon ^b, Damien Leger ^b, Ciara Bergin ^d, Ali Dirani ^d, Talal Beydoun ^a, Francine Behar-Cohen ^c,^d
^a Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France
^b Sleep and Vigilance Center, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France
^c Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France
^d Department of Ophthalmology University of Lausanne, Jules Gonin Ophthalmic Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland

^∗Inquiries to Elodie Bousquet, Hôpital Hôtel Dieu, 1 Parvis Notre Dame, 75004 Paris, FranceHôpital Hôtel Dieu1 Parvis Notre DameParis75004France

Abstract

Purpose

To investigate if shift work or sleep disturbances are risk factors for central serous chorioretinopathy (CSCR).

Design

Prospective case-control study.

Methods

Forty patients with active CSCR and 40 controls (age- and sex-matched) were prospectively recruited from the Ophthalmology Department of Hôtel Dieu Hospital, Paris, between November 2013 and December 2014. All patients were asked to complete a questionnaire addressing previously described risk factors and working hours, as well as the Insomnia Severity Index (ISI), a validated instrument for assessing sleep disturbances.

Results

The mean age of the CSCR group was 44 ± 9 years, whereas the mean age of the control group was 43 ± 10 years. By use of multivariate analysis, shift work (odds ratio [OR] [95% confidence interval]: 5 [1.2–20.4]; P = .02), steroid use (OR: 5.5 [1.1–26.2]; P = .03), and recent psychological stress (OR: 15.3 [4.1–54.5]; P < .001) were found to be independently associated with CSCR.

Conclusion

The outcomes of this study suggest that shift work is an independent risk factor of CSCR. Further studies are required to confirm these results and to examine if work reconversion would be beneficial in the treatment of patients with chronic/recurrent CSCR.

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Plan

Methods

Study Patients

Study Protocol

Insomnia Severity Index

Statistical Analysis

Results

Patient Characteristics

Univariate Analysis

Multivariate Logistic Regression Analysis

Discussion

Supplemental Material available at AJO.com.

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Vol 165

P. 23-28 - mai 2016 Retour au numéro

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Shift Work: A Risk Factor for Central Serous Chorioretinopathy - 14/05/16

Abstract

Purpose

Design

Methods

Results

Conclusion

Plan

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