A novel, ring-connected stent versus conventional GI stents: comparative study of physical properties and migration rates in a canine colon obstruction model - 01/06/16
Abstract |
Background |
Migration of stents is one of the most common adverse events in covered stent placement in GI tract obstruction.
Objective |
To compare physical property and migration rates in a canine colon obstruction model among a novel stent and conventional stents.
Design |
Comparative physical test and animal study.
Setting |
Medical device testing laboratory and animal laboratory.
Subjects |
Mongrel dogs (N = 26).
Interventions |
Surgical colon obstruction followed by placement of a novel (n = 13) or conventional (n = 13) stent.
Main Outcome Measurements |
Physical properties, migration, and adverse events.
Results |
The novel stent showed better flexibility, as in a physical test of longitudinal compressibility and axial force, than did conventional stents, and it withstood the fatigue test for 10 days. In terms of radial force and tensile strength, the novel stent showed the same or better results than conventional stents. In a canine colon obstruction model, the migration rate of a novel stent was significantly lower than that of a conventional stent (2/13, 15.4% vs 8/13, 61.5%; P = .008).
Limitations |
Animal study of limited size.
Conclusion |
The novel, ring-connected stent is more flexible and more resistant to migration than the conventional stents.
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| DISCLOSURE: Hong Suk Park, In Wook Choo, Soowon Seo, and Jae J. Kim are co-inventors of the novel stent. The patent, owned by Samsung Life Public Welfare Foundation, was granted in the Republic of Korea and is pending in the United States. All stents for the physical test and the animal experiments were provided free of charge by Standard Sci-Tech Inc and M.I. Tech Co Ltd. This study was supported by a Samsung Medical Center research grant (SMX1140121). All other authors disclosed no financial relationships relevant to this article. |
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| If you would like to chat with an author of this article, you may contact Dr In Wook Choo at inwookchoo@gmail.com. |
Vol 81 - N° 6
P. 1433-1438 - juin 2015 Retour au numéro
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