The discovery of IgE - 03/06/16
Doi : 10.1016/j.jaci.2016.04.004
S.G.O. Johansson, MD, PhD ⁎ 
Department of Medicine, Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
∗Corresponding author: S. G. O. Johansson, MD, PhD, Immunology and Allergy Unit, Karolinska University Hospital, Solna, L2:04, S-17176 Stockholm.Immunology and Allergy UnitKarolinska University HospitalSolna, L2:04StockholmS-17176
Abstract |
In 1919, the search began for the factor, later called reagin, that could mediate an allergy, such as allergic asthma, in sera of allergic subjects. In 1967, the fifth class of immunoglobulins, IgE, was discovered and found to be able to carry reagin activity. This discovery has had immense importance for the understanding, diagnosis, and treatment of allergic diseases.
Le texte complet de cet article est disponible en PDF.Key words : Allergy, inflammation, mast cell, immunoglobulin, sensitization, reagin
Abbreviation used : RAST
| Disclosure of potential conflict of interest: S. G. O. Johansson declares no relevant conflicts of interest. |
© 2016
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 137 - N° 6
P. 1671-1673 - juin 2016 Retour au numéro
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