Postoperative prognostic nutritional index change is an independent predictor of survival in patients with small hepatocellular carcinoma - 20/06/16
, Lv-Nan Yan, M.D., Bo Li, M.D., Wen-Tao Wang, M.D., Jia-Yin Yang, M.D., Ming-Qing Xu, M.D.Abstract |
Background |
There is limited information concerning the postoperative prognostic nutritional index change (ΔPNI) in hepatocellular carcinoma (HCC). This study was designed to evaluate the prognostic value of ΔPNI in patients with small HCC who underwent liver resection.
Methods |
A retrospective cohort study was performed to analyze 243 patients with small HCC who underwent liver resection. Patients were divided into prognostic nutritional index (PNI)–increased group (n = 161) and PNI-decreased group (n = 82) according to postoperative PNI change. Clinical data, overall survival (OS), and recurrence-free survival (RFS) were statistically compared between the 2 groups, and a multivariate analysis was used to identify prognostic factors.
Results |
Multivariable analysis revealed that ΔPNI as independent predictors of OS and RFS in patients with small HCC after liver resection (P < .01 for both).
Conclusions |
Decreased PNI, but not low preoperative PNI was an independent risk factor for OS and RFS in patients with small HCC who underwent liver resection.
Le texte complet de cet article est disponible en PDF.Highlights |
• | We evaluated the ΔPNI in small HCC patients who underwent liver resection. |
• | In those patients, decreased PNI predicts worse OS and RFS but not pre- or post-PNI. |
• | We found that post-ΔPNI as independent predictors of OS and RFS in those patients. |
Keywords : Prognostic nutritional index, Hepatocellular carcinoma, Milan criteria, Prognostic factor, Liver resection
Plan
| We declare that no proprietary or commercial interest in any product mentioned or concept discussed in the article. |
Vol 212 - N° 1
P. 122-127 - juillet 2016 Retour au numéro
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