MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis - 04/08/16
Doi : 10.1016/j.jaci.2016.03.025
Jean Bousquet, MD a, b, c, ⁎ 
, Holger J. Schünemann, MD d, Peter W. Hellings, MD e, Sylvie Arnavielhe, PhD f, Claus Bachert, MD g, Anna Bedbrook, BSc b, Karl-Christian Bergmann, MD h, Sinthia Bosnic-Anticevich, PhD i, Jan Brozek, MD d, Moises Calderon, MD j, G. Walter Canonica, MD k, Thomas B. Casale, MD l, Niels H. Chavannes, MD m, Linda Cox, MD n, Henry Chrystyn, PhD o, Alvaro A. Cruz, MD p, Ronald Dahl, MD q, Giuseppe De Carlo, MD r, Pascal Demoly, MD s, t, Phillipe Devillier, MD u, Gérard Dray, PhD v, Monica Fletcher, MSc w, Wytske J. Fokkens, MD x, Joao Fonseca, MD y, Sandra N. Gonzalez-Diaz, MD z, Lawrence Grouse, MD aa, Thomas Keil, MD bb, Piotr Kuna, MD cc, Désirée Larenas-Linnemann, MD dd, Karin C. Lodrup Carlsen, MD ee, Eli O. Meltzer, MD ff, Jaoquim Mullol, MD gg, Antonella Muraro, MD hh, Robert N. Naclerio, MD ii, Susanna Palkonen, MD r, Nikolaos G. Papadopoulos, MD jj, Giovanni Passalacqua, MD k, David Price, MD kk, Dermot Ryan, MD ll, Boleslaw Samolinski, MD mm, Glenis K. Scadding, MD nn, Aziz Sheikh, MD oo, François Spertini, MD pp, Arunas Valiulis, MD qq, Erkka Valovirta, MD rr, Samantha Walker, PhD ss, Magnus Wickman, MD tt, Arzu Yorgancioglu, MD uu, Tari Haahtela, MD vv, Torsten Zuberbier, MD h
on behalf of the
, Holger J. Schünemann, MD d, Peter W. Hellings, MD e, Sylvie Arnavielhe, PhD f, Claus Bachert, MD g, Anna Bedbrook, BSc b, Karl-Christian Bergmann, MD h, Sinthia Bosnic-Anticevich, PhD i, Jan Brozek, MD d, Moises Calderon, MD j, G. Walter Canonica, MD k, Thomas B. Casale, MD l, Niels H. Chavannes, MD m, Linda Cox, MD n, Henry Chrystyn, PhD o, Alvaro A. Cruz, MD p, Ronald Dahl, MD q, Giuseppe De Carlo, MD r, Pascal Demoly, MD s, t, Phillipe Devillier, MD u, Gérard Dray, PhD v, Monica Fletcher, MSc w, Wytske J. Fokkens, MD x, Joao Fonseca, MD y, Sandra N. Gonzalez-Diaz, MD z, Lawrence Grouse, MD aa, Thomas Keil, MD bb, Piotr Kuna, MD cc, Désirée Larenas-Linnemann, MD dd, Karin C. Lodrup Carlsen, MD ee, Eli O. Meltzer, MD ff, Jaoquim Mullol, MD gg, Antonella Muraro, MD hh, Robert N. Naclerio, MD ii, Susanna Palkonen, MD r, Nikolaos G. Papadopoulos, MD jj, Giovanni Passalacqua, MD k, David Price, MD kk, Dermot Ryan, MD ll, Boleslaw Samolinski, MD mm, Glenis K. Scadding, MD nn, Aziz Sheikh, MD oo, François Spertini, MD pp, Arunas Valiulis, MD qq, Erkka Valovirta, MD rr, Samantha Walker, PhD ss, Magnus Wickman, MD tt, Arzu Yorgancioglu, MD uu, Tari Haahtela, MD vv, Torsten Zuberbier, MD hon behalf of the
MASK study group*
Werner Aberer, MD, Mitsuru Adachi, MD, Ioana Agache, MD, Cezmi Akdis, MD, Mubeccel Akdis, MD, Isabella Annesi-Maesano, MD, Ignacio J. Ansotegui, MD, Josep M. Anto, MD, S. Hasan Arshad, MD, Ilaria Baiardini, MD, Abay K. Baigenzhin, MD, Cristina Barbara, MD, Eric D. Bateman, MD, Bianca Beghé, MD, Elisabeth H. Bel, MD, Ali Ben Kheder, MD, Kazi S. Bennoor, MD, Michael Benson, MD, David Bernstein, MD, Bewick Michael, MD, Bieber Thomas, MD, Carsten Bindslev-Jensen, MD, Leif Bjermer, MD, Hubert Blain, MD, Attilio Boner, MD, Matteo Bonini, MD, Sergio Bonini, MD, Isabelle Bosse, MD, Jacques Bouchard, MD, Louis-Philippe Boulet, MD, Rodolphe A. Bourret, PhD, Philippe J. Bousquet, MD, Fulvio Braido, MD, Andrew H. Briggs, PhD, Christopher E. Brightling, MD, Roland Buhl, MD, Peter Burney, MD, Andrew Bush, MD, Fernando Caballero-Fonseca, MD, Davide P. Caimmi, MD, Paulo Camargos, MD, Thierry Camuzat, Kai-Hakon Carlsen, MD, Warner Carr, MD, Thomas B. Casale, MD, Alfonso Cepeda Sarabia, MD, Leda Chatzi, PhD, Yuzhi Chen, MD, Raphaël Chiron, MD, Ekaterine Chkhartishvili, MD, Alexander Chuchalin, MD, Georgio Ciprandi, MD, Ieva Cirule, Jaime Correia de Sousa, MD, David Costa, MD, George Crooks, MD, Adnan Custovic, MD, Sven-Erik Dahlen, MD, Ulf Darsow, MD, Frédéric De Blay, MD, Esteban De Manuel Keenoy, MD, Tony Dedeu, MD, Diana Deleanu, MD, Judah Denburg, MD, Alain Didier, MD, Anh-Tuan Dinh-Xuan, MD, Dejan Dokic, MD, Habib B. Douagui, MD, Ruta Dubakiene, MD, Stephen Durham, MD, Mark Dykewicz, MD, Yehia El-Gamal, MD, Regina Emuzyte, MD, Antje Fink-Wagner, PhD, Alessandro Fiocchi, MD, Francesco Forastiere, MD, Amiran Gamkrelidze, MD, Bilun Gemicioğlu, MD, Jose E. Gereda, MD, Roy Gerth van Wijk, MD, Maia Gotua, MD, Ineta Grisle, MD, M. Antonieta Guzmán, MD, Tari Haahtela, MD, Joachim Heinrich, PhD, Birthe Hellquist-Dahl, PhD, Friedrich Horak, MD, Peter H. Howarth, MD, Marc Humbert, MD, Michael Hyland, PhD, Juan-Carlos Ivancevich, MD, Edgardo J. Jares, MD, Sebastian L. Johnston, MD, Olivier Jonquet, MD, Guy Joos, MD, Ki-Suck Jung, MD, Jocelyne Just, MD, Marek Jutel, MD, Igor P. Kaidashev, MD, Musa Khaitov, MD, Omer Kalayci, MD, Fuat Kalyoncu, MD, Paul Keith, MD, Nikolai Khaltaev, MD, Jorg Kleine-Tebbe, MD, Ludger Klimek, MD, Bernard Koffi N'Goran, MD, Vitezlav Kolek, MD, Gerard H. Koppelman, MD, Marek Kowalski, MD, Inger Kull, PhD, Violeta Kvedariene, MD, Bart Lambrecht, MD, Susanne Lau, MD, Daniel Laune, PhD, Lan Le Thi Tuyet, MD, Jing Li, MD, Phillipe Lieberman, MD, Brian J. Lipworth, MD, Louis Renaud, MD, Yves Magard, MD, Antoine Magnan, MD, Bassam Mahboub, MD, Ivan Majer, MD, Mika Makela, MD, Peter J. Manning, MD, Mohamad R. Masjedi, MD, Marcus Maurer, MD, Sandra Mavale-Manuel, MD, Erik Melén, MD, Elisabete Melo-Gomes, MD, Jacques Mercier, MD, Hans Merk, MD, Neven Miculinic, MD, Florin Mihaltan, MD, Branislava Milenkovic, MD, Yousser Mohammad, MD, Mathieu Molimard, MD, Isabelle Momas, PhD, Anna Montilla-Santana, MD, Mario Morais-Almeida, MD, Ralph Mösges, MD, Rachel Nadif, PhD, Leyla Namazova-Baranova, MD, Hugo Neffen, MD, Kristof Nekam, MD, Angelos Neou, MD, Bodo Niggemann, MD, Dieudonné Nyembue, MD, Robyn O'Hehir, MD, Ken Ohta, MD, Yoshitaka Okamoto, MD, Kim Okubo, MD, Solange Ouedraogo, MD, Pier-Luigi Paggiaro, MD, Isabella Pali-Schöll, MD, Stephen Palmer, MSc, Petr Panzner, MD, Alberto Papi, MD, Hae-Sim Park, MD, Ian Pavord, MD, Ruby Pawankar, MD, Oliver Pfaar, MD, Robert Picard, PhD, Bernard Pigearias, MD, Isabelle Pin, MD, Davor Plavec, MD, Wolfgang Pohl, MD, Todor Popov, MD, Dirkje S. Postma, MD, Paul Potter, MD, Lars K. Poulsen, PhD, Klaus F. Rabe, MD, Filip Raciborski, PhD, Françoise Radier Pontal, MD, Sakari Reitamo, MD, Maria-Susana Repka-Ramirez, MD, Carlos Robalo-Cordeiro, MD, Graham Roberts, MD, Francisco Rodenas, PhD, Christine Rolland, MD, Miguel Roman Rodriguez, MD, Antonino Romano, MD, José Rosado-Pinto, MD, Nelson A. Rosario, MD, Larry Rosenwasser, MD, Menachem Rottem, MD, Mario Sanchez-Borges, MD, Joaquim Sastre-Dominguez, MD, Peter Schmid-Grendelmeier, MD, Eli Serrano, MD, F. Estelle R. Simons, MD, Juan-Carlos Sisul, MD, Ingebjorg Skrindo, MD, Henriette A. Smit, PhD, Dirceu Solé, MD, Talant Sooronbaev, MD, Otto Spranger, Rafael Stelmach, MD, Timo Strandberg, MD, Jordi Sunyer, MD, Carel Thijs, MD, Ana-Maria Todo-Bom, MD, Massimo Triggiani, MD, Rudolf Valenta, MD, Antonio L. Valero, MD, Marianne van Hage, MD, Olivier Vandenplas, MD, Giorgio Vezzani, MD, Pakit Vichyanond, MD, Giovanni Viegi, MD, Martin Wagenmann, MD, Ulrich Wahn, MD, Wang De Yun, MD, Denis Williams, PhD, John Wright, MD, Barbara P. Yawn, MD, Panayiotis Yiallouros, MD, Osman M. Yusuf, MD, Heather J. Zar, MD, Mario Zernotti, MD, Luo Zhang, MD, Nanshan Zhong, MD, Mihaela Zidarn, MD
a University Hospital, Montpellier, France
b MACVIA-LR, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France
c INSERM, VIMA: Ageing and Chronic Diseases, Epidemiological and Public Health approaches, Paris, and Université Versailles St-Quentin-en-Yvelines, St-Quentin-en-Yvelines, France
d Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario, Canada
e Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
f Kyomed, Montpellier, France
g Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium
h Allergy-Centre-Charité at the Department of Dermatology, Charité–Universitätsmedizin Berlin, and Secretary General of the Global Allergy and Asthma European Network (GA2LEN), Berlin, Germany
i Woolcock Institute of Medical Research, University of Sydney and Sydney Local Health District, Glebe, Australia
j Imperial College London–National Heart and Lung Institute, Royal Brompton Hospital NHS, London, United Kingdom
k Allergy and Respiratory Diseases Clinic, DIMI, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy
l Division of Allergy/Immunology, University of South Florida, Tampa, Fla
m Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
n Department of Medicine, Nova Southeastern University, Davie, Fla
o RiRL, Cambridge, United Kingdom
p ProAR–Nucleo de Excelencia em Asma, Federal University of Bahia, and GARD Executive Committee, Bahia, Brazil
q Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark
r EFA European Federation of Allergy and Airways Diseases Patients' Associations, Brussels, Belgium
s EPAR U707 INSERM, Paris and EPAR UMR-S UPMC, Paris VI, Paris, France
t Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France
u Laboratoire de Pharmacologie Respiratoire UPRES EA220, Hôpital Foch, Suresnes Université Versailles Saint-Quentin, St-Quentin-en-Yvelines, France
v Ecole des Mines, Alès, France
w Education for Health, Warwick, United Kingdom
x Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands
y Center for Research in Health Technologies and Information Systems–CINTESIS, Universidade do Porto; the Allergy Unit, Instituto CUF Porto e Hospital CUF Porto; the Health Information and Decision Sciences Department–CIDES, Faculdade de Medicina, Universidade do Porto; Faculdade de Medicina da Universidade do Porto, Porto, Portugal
z Universidad Autónoma de Nuevo León, Nuevo León, Mexico
aa University of Washington School of Medicine, Faculty of the Department of Neurology, Seattle, Wash
bb Institute of Social Medicine, Epidemiology and Health Economics, Charité–Universitätsmedizin Berlin, and the Institute for Clinical Epidemiology and Biometry, University of Wuerzburg, Wuerzburg, Germany
cc Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
dd Clínica de Alergia, Asma y Pediatría, Hospital Médica Sur, Mexico City, Mexico
ee Department of Paediatrics, Oslo University Hospital, Oslo, and the Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
ff Allergy and Asthma Medical Group and Research Center, San Diego, Calif
gg Unitat de Rinologia i Clínica de l'Olfacte, Servei d'ORL, Hospital Clínic, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, Barcelona, Spain
hh Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy
ii Section of Otolaryngology-Head and Neck Surgery, University of Chicago Medical Center and Pritzker School of Medicine, University of Chicago, Chicago, Ill
jj Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children's Hospital, University of Manchester, and the Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital “P&A Kyriakou”, University of Athens, Athens, Greece
kk Academic Centre of Primary Care, University of Aberdeen, and Research in Real-Life, Cambridge, United Kingdom
ll Honorary Clinical Research Fellow, Allergy and Respiratory Research Group, University of Edinburgh, Edinburgh, United Kingdom
mm Department of Prevention of Envinronmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland
nn Royal National TNE Hospital, University College London, London, United Kingdom
oo Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
pp Service d'Immunologie et Allergie, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
qq Vilnius University Clinic of Children's Diseases, Vilnius, Lithuania
rr Department of Lung Diseases and Clinical Allergology, University of Turku, Turku, Finland
ss Asthma UK, London, United Kingdom
tt Sachs' Children's Hospital, Stockholm, and the Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
uu Department of Pulmonology, Celal Bayar University Manisa, Turkey, and GARD Executive Committee, Manisa, Turkey
vv Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland
∗Corresponding author: Jean Bousquet, MD, CHRU Arnaud de Villeneuve, Département de Pneumologie, 371 Avenue du Doyen Gaston, Giraud, 34295 Montpellier Cedex 5, France.CHRU Arnaud de VilleneuveDépartement de Pneumologie371 Avenue du Doyen Gaston, GiraudMontpellier Cedex 534295France
Abstract |
The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR [fighting chronic diseases for active and healthy ageing]), one of the reference sites of the European Innovation Partnership on Active and Healthy Ageing, has initiated an allergy sentinel network (the MACVIA-ARIA Sentinel Network). A CDSS is currently being developed to optimize AR control. An algorithm developed by consensus is presented in this article. This algorithm should be confirmed by appropriate trials.
Le texte complet de cet article est disponible en PDF.Key words : Allergic rhinitis, conjunctivitis, Allergic Rhinitis and its Impact on Asthma, MACVIA-LR, information and communication technology, clinical decision support system
Abbreviations used : AR, CDSS, MACVIA-LR, MASK, MCID, QOL, RQLQ, VAS
Plan
| Working group members*: Werner Aberer, MD; Mitsuru Adachi, MD; Ioana Agache, MD; Cezmi Akdis, MD; Mubeccel Akdis, MD; Isabella Annesi-Maesano, MD; Ignacio J. Ansotegui, MD; Josep M. Anto, MD; S. Hasan Arshad, MD; Ilaria Baiardini, MD; Abay K.Baigenzhin, MD; Cristina Barbara, MD; Eric D. Bateman, MD; Bianca Beghé, MD; Elisabeth H. Bel, MD; Ali Ben Kheder, MD; Kazi S. Bennoor, MD; Michael Benson, MD; David Bernstein, MD; Bewick Michael, MD; Bieber Thomas, MD; Carsten Bindslev-Jensen, MD; Leif Bjermer, MD; Hubert Blain, MD; Attilio Boner, MD; Matteo Bonini, MD; Sergio Bonini, MD; Isabelle Bosse, MD; Jacques Bouchard, MD; Louis-Philippe Boulet, MD; Rodolphe A. Bourret, PhD; Philippe J. Bousquet, MD; Fulvio Braido, MD; Andrew H. Briggs, PhD; Christopher E. Brightling, MD; Roland Buhl, MD; Peter Burney, MD; Andrew Bush, MD; Fernando Caballero-Fonseca, MD; Davide P. Caimmi, MD; Paulo Camargos, MD; Thierry Camuzat; Kai-Hakon Carlsen, MD; Warner Carr, MD; Thomas B. Casale, MD; Alfonso Cepeda Sarabia, MD; Leda Chatzi, PhD; Yuzhi Chen, MD; Raphaël Chiron, MD; Ekaterine Chkhartishvili, MD; Alexander Chuchalin, MD; Georgio Ciprandi, MD; Ieva Cirule; Jaime Correia de Sousa, MD; David Costa, MD; George Crooks, MD; Adnan Custovic, MD; Sven-Erik Dahlen, MD; Ulf Darsow, MD; Frédéric De Blay, MD; Esteban De Manuel Keenoy, MD; Tony Dedeu, MD; Diana Deleanu, MD; Judah Denburg, MD; Alain Didier, MD; Anh-Tuan Dinh-Xuan, MD; Dejan Dokic, MD; Habib B. Douagui, MD; Ruta Dubakiene, MD; Stephen Durham, MD; Mark Dykewicz, MD; Yehia El-Gamal, MD; Regina Emuzyte, MD; Antje Fink-Wagner, PhD; Alessandro Fiocchi, MD; Francesco Forastiere, MD; Amiran Gamkrelidze, MD; Bilun Gemicioğlu, MD; Jose E. Gereda, MD; Roy Gerth van Wijk, MD; Maia Gotua, MD; Ineta Grisle, MD; M. Antonieta Guzmán, MD; Tari Haahtela, MD; Joachim Heinrich, PhD; Birthe Hellquist-Dahl, PhD; Friedrich Horak, MD; Peter H. Howarth, MD; Marc Humbert, MD; Michael Hyland, PhD; Juan-Carlos Ivancevich, MD; Edgardo J. Jares, MD; Sebastian L. Johnston, MD; Olivier Jonquet, MD; Guy Joos, MD; Ki-Suck Jung, MD; Jocelyne Just, MD; Marek Jutel, MD; Igor P. Kaidashev, MD; Musa Khaitov, MD; Omer Kalayci, MD; Fuat Kalyoncu, MD; Paul Keith, MD; Nikolai Khaltaev, MD; Jorg Kleine-Tebbe, MD; Ludger Klimek, MD; Bernard Koffi N'Goran, MD; Vitezlav Kolek, MD; Gerard H. Koppelman, MD; Marek Kowalski, MD; Inger Kull, PhD; Violeta Kvedariene, MD; Bart Lambrecht, MD; Susanne Lau, MD; Daniel Laune, PhD; Lan Le Thi Tuyet, MD; Jing Li, MD; Phillipe Lieberman, MD; Brian J. Lipworth, MD; Louis Renaud, MD; Yves Magard, MD; Antoine Magnan, MD; Bassam Mahboub, MD; Ivan Majer, MD; Mika Makela, MD; Peter J. Manning, MD; Mohamad R. Masjedi, MD; Marcus Maurer, MD; Sandra Mavale-Manuel, MD; Erik Melén, MD; Elisabete Melo-Gomes, MD; Jacques Mercier, MD; Hans Merk, MD; Neven Miculinic, MD; Florin Mihaltan, MD; Branislava Milenkovic, MD; Yousser Mohammad, MD; Mathieu Molimard, MD; Isabelle Momas, PhD; Anna Montilla-Santana, MD; Mario Morais-Almeida, MD; Ralph Mösges, MD; Rachel Nadif, PhD; Leyla Namazova-Baranova, MD; Hugo Neffen, MD; Kristof Nekam, MD; Angelos Neou, MD; Bodo Niggemann, MD; Dieudonné Nyembue, MD; Robyn O'Hehir, MD; Ken Ohta, MD; Yoshitaka Okamoto, MD; Kim Okubo, MD; Solange Ouedraogo, MD; Pier-Luigi Paggiaro, MD; Isabella Pali-Schöll, MD; Stephen Palmer, MSc; Petr Panzner, MD; Alberto Papi, MD; Hae-Sim Park, MD; Ian Pavord, MD; Ruby Pawankar, MD; Oliver Pfaar, MD; Robert Picard, PhD; Bernard Pigearias, MD; Isabelle Pin, MD; Davor Plavec, MD; Wolfgang Pohl, MD; Todor Popov, MD; Dirkje S. Postma, MD; Paul Potter, MD; Lars K. Poulsen, PhD; Klaus F. Rabe, MD; Filip Raciborski, PhD; Françoise Radier Pontal, MD; Sakari Reitamo, MD; Maria-Susana Repka-Ramirez, MD; Carlos Robalo-Cordeiro, MD; Graham Roberts, MD; Francisco Rodenas, PhD; Christine Rolland, MD; Miguel Roman Rodriguez, MD; Antonino Romano, MD; José Rosado-Pinto, MD; Nelson A. Rosario, MD; Larry Rosenwasser, MD; Menachem Rottem, MD; Mario Sanchez-Borges, MD; Joaquim Sastre-Dominguez, MD; Peter Schmid-Grendelmeier, MD; Eli Serrano, MD; F. Estelle R. Simons, MD; Juan-Carlos Sisul, MD; Ingebjorg Skrindo, MD; Henriette A. Smit, PhD; Dirceu Solé, MD; Talant Sooronbaev, MD; Otto Spranger; Rafael Stelmach, MD; Timo Strandberg, MD; Jordi Sunyer, MD; Carel Thijs, MD; Ana-Maria Todo-Bom, MD; Massimo Triggiani, MD; Rudolf Valenta, MD; Antonio L. Valero, MD; Marianne van Hage, MD; Olivier Vandenplas, MD; Giorgio Vezzani, MD; Pakit Vichyanond, MD; Giovanni Viegi, MD; Martin Wagenmann, MD; Ulrich Wahn, MD; Wang De Yun, MD; Denis Williams, PhD; John Wright, MD; Barbara P. Yawn, MD; Panayiotis Yiallouros, MD; Osman M. Yusuf, MD; Heather J. Zar, MD; Mario Zernotti, MD; Luo Zhang, MD; Nanshan Zhong, MD; Mihaela Zidarn, MD. |
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| Disclosure of potential conflict of interest: J. Bousquet has received consulting fees from Actelion, Almirall, Meda, Merck, Merck Sharp Dohme, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach; has received fees for participation in review activities from Almirall, AstraZeneca, Chiesi, GlaxoSmithKline, Meda, Merck, Merck Sharp Dohme, Novartis, OM Pharma, Sanofi-Aventis, Schering-Plough, Takeda, Teva, and Uriach; has received lecture fees from Almirall, AstraZeneca, Chiesi, GlaxoSmithKline, Meda, Merck, Merck Sharp Dohme, Novartis, OM Pharma, Sanofi-Aventis, Schering-Plough, Takeda, Teva, and Uriach; and has received payment for development of educational presentations from Almirall, AstraZeneca, Chiesi, GlaxoSmithKline, Meda, Merck, Merck Sharp Dohme, Novartis, OM Pharma, Sanofi-Aventis, Schering-Plough, Takeda, Teva, and Uriach. K.-C. Bergmann has received lecture fees from Novartis. S. Bosnic-Anticevich is a member of the Teva Pharmaceuticals Devices International Key Experts Panel, has received research support from Research in Real Life, and has received lecture fees and payment for developing educational presentations from Teva and Mundipharma. G. W. Canonica is on the Board for and has received consultancy and lecture fees from ALK-Abelló, Allergopharma, Allergy Therapeutics, Anallergo, Hal, Lofarma, Stallergenes, and Thermo Fisher. T. B. Casale is Executive Vice President of the American Academy of Allergy, Asthma & Immunology (AAAAI). L. Cox has received consultancy fees from Genentech and Allergopharma; has received fees for participation in review activities from Circassia and Biomay; is on the ABAI Board; was on the AAAAI Board; and has received lecture fees from several regional, local, and state allergy meetings. A. A. Cruz is on the Meda Pharma Board, has received research support from GlaxoSmithKline, and has received lecture fees and travel support from Meda. R. Dahl has received lecture fees from Boehringer Ingelheim, AstraZeneca, GlaxoSmithKline, ALK-Abelló, Cipla, Novartis, Meda, and Chiesi. G. De Carlo has received research support from Sanofi Pasteur MSD, Boehringer Ingelheim International, ALK-Abelló, Almirall, Stallergenes France, Air Liquide Sante International, Novartis, GlaxoSmithKline, Mundipharma, and Chiesi. P. Demoly has received consultancy fees from ALK-Abelló, Circassia, Stallergenes, ThermoFisher Scientific, DBV, and Chiesi and has received lecture fees from Menarini, AstraZeneca, GlaxoSmithKline, Allergopharma, and MSD. P. Devillier is on the Meda Pharma Board; has received consultancy fees from Stallergenes, ALK-Abelló, and GlaxoSmithKline; has received lecture fees from Stallergenes and ALK-Abelló; has received payment for manuscript preparation from Stallergenes; and has received travel support from Stallergenes and Meda. M. Fletcher has received consultancy fees from AstraZeneca, Boehringer Ingelheim, Napp, and Teva and has received lecture fees from AstraZeneca, Boehringer Ingelheim, Napp, Novartis, and Teva. W. J. Fokkens has received research support from Meda and has received payment for developing a webcast on treatment of rhinitis for general practitioners. J. Fonseca is on the Boehringer Ingelheim and Novartis Boards; has received consultancy fees from Novartis; has received research support from Fundação Ciência e Tecnologia and Fundação Calouste Gulbenkian; has received lecture fees from AstraZeneca, Aerocrine, Menarini, GlaxoSmithKline, MSD, and Vitoria; and has received travel support from AstraZeneca and Novartis. T. Keil has received research support from the European Union projects MeDALL and iFAAM. P. Kuna has received lecture fees from Adamed, Allergopharma, Almirall, AstraZeneca, GlaxoSmithKline, Hal, Meda, Pfizer, Polpharma, Stallergenes, Lekam, and Bayer and has received lecture fees and is on the advisory board from Boehringer Ingelheim, Celon Pharma, Chiesi, FAES, MSD, Novartis, Polpharma, and Teva. D. Larenas-Linnemann has received consultancy fees from Boehringer Ingelheim, Meda, Pfizer, Mit Pharma, and Chiesi; has received research support from AstraZeneca, MSD, Novartis, Sanofi, UCB, GlaxoSmithKline, Pfizer, MEDA, TEVA, Senosiain, Carnot; has received lecture fees from AstraZeneca, MSD, Movartis, Sanofi, Pfizer, and Meda; has received payment for development of educational presentations from Glenmark; and has received travel support from ALK-Abelló. K. C. Lodrup Carlsen has received research and travel support from EU MedALL, is on the Sanofi advisory board, has received research support from National and regional public funding applications. E. O. Meltzer has received consultancy fees from AstraZeneca, Boehringer Ingelheim, Church & Dwight, GlaxoSmithKline, Greer, Johnson & Johnson, Meda, Mylan, Regeneron/Sanofi, and Teva; is self-employed; has received lecture fees from Greer, Meda, Merck, Mylan, Takeda, and Teva; and has received payment for developing educational presentations from Glenmark. J. Mullol is on the boards for Uriach, Meda, FAES, ALK-Abelló, and Sanofi; has received research support from GlaxoSmithKline, Uriach, FAES, and Meda; and has received lecture fees from Uriach, Hartington Pharmaceuticals, Novartis, FAES, Menarini, MSD, Pierre-Fabre, and UCB. A. Muraro has received consultancy fees from Meda. R. N. Naclerio is on the Merck and Sanofi allergy advisory boards, has received consultancy fees from Teva, is employed by the University of Chicago, and has received research support from Meda. S. Palkonen is on the GlaxoSmithKline European Health Advisory Board; has received research support from Air Liquide Sante International, ALK-Abelló, Almirall, Boehringer Ingelheim, GlaxoSmithKline, Novartis, Chiesi, Mundipharma, Sanofi-Pasteur, and Stallergenes; has received travel support from Novartis; and declares that she regularly has dialogue with the funding partners listed above, who give unrestricted educational grants to the patient organization, EFA, for which she works as a Director. N. Papadopoulos has received research support from GlaxoSmithKline, Nestle, and Merck; has received payment for developing educational presentations from Abbvie, Sanofi, Menarini, and Meda; has received consultancy fees from GlaxoSmithKline, Abbvie, Novartis, Menarini, Meda, and ALK-Abelló; and has received lecture fees from Allergopharma, Uriach, GlaxoSmithKline, Stallergenes, and MSD. D. Price is on the boards for Aerocrine, Almirall, Amgen, AstraZeneca, Boehringer Ingelheim, Chiesi, Meda, Mundipharma, Napp, Novartis, and Teva; has received consultancy fees from Almirall, Amgen, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Meda, Mundipharma, Napp, Novartis, Pfizer, and Teva; has received research support from the UK National Health Service, British Lung Foundation, Aerocrine, AKL Ltd, Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, Eli Lilly, GlaxoSmithKline, Meda, Merck, Mundipharma, Napp, Novartis, Orion, Pfizer, Respiratory Effectiveness Group, Takeda, Teva, Zentiva; has received lecture fees from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, GlaxoSmithKline, Kyorin, Meda, Merck, Mundipharma, Novartis, Pfizer, SkyePharma, Takeda, and Teva; has received payment for manuscript preparation from Mundipharma and Teva; has a patent with AKL Ltd; has received payment for developing educational presentations from GlaxoSmithKline and Novartis; has stock in AKL Ltd; has received travel support from Aerocrine, Boehringer Ingelheim, Mundipharma, Napp, Novartis, and Teva; has received funding for patient enrolment or completion of research from Almirall, Chiesi, Teva, and Zentiva; has served as a peer reviewer for grant committees for the Medical Research Council, Efficacy and Mechanism Evaluation Programme, and HTA; and is 80% owner of Research in Real Life, which receives unrestricted funding for investigator-initiated studies from Aerocrine, AKL Ltd, Almirall, Boehringer Ingelheim, Chiesi, Meda, Mundipharma, Napp, Novartis, Orion, Takeda, Teva, and Zentiva. D. Ryan is on the Boards for Stallergenes and Uriach; has received consultancy fees from Meda; is employed by Optimum Patient Care and University of Edinburgh; has received lecture fees from Meda, Chiesi, Teva, AstraZeneca, and Boehringer Ingelheim; has received payment for developing educational presentation from Meda; and is Chairman of the European Academy of Allergy and Clinical Immunology (EAACI) Primary Care Interest Group. A. Valiulis is a board member without financial interest of the nonprofit organizations the European Academy of Paediatrics, European Paediatrc Association, European Confederation of Primary Care Paediatricians, Lithuanian Paediatric Society, and Lithuanian Paediatric Respiratory Society; has received research support from European Union Social Fund and Lithuanian Ministry of Health; has received travel support from the European Academy of Pediatrics; is Chairman of Executive Board of IPOKRaTES Lithuania Fund. E. Valovirta has received travel support from Stallergenes. M. Wickman has received research support and lecture fees from Thermo Fisher, has received consultancy fees from Thermo Fisher and Microtest Dx, and has received payment for developing educational presentations from Stallergenes. T. Zuberbier has received consultancy fees from Ansell, Bayer Schering, DST, FAES, Fujisawa, HAL, Henkel, Kryolan, Leti, Menarini, Merck, MSD, Novartis, Procter & Gamble, Ranbaxy, Sanofi-Aventis, Schering Plough, Stallergenes, Takeda, and UCB; is on the German Society for Allergy and Clinical Immunology Scientific Advisory Board; is head of the European Centre for Allergy Research Foundation; is a World Health Organization Initiative Allergic Rhinitis and its Impact on Asthma committee member; is a member of the World Allergy Organization Communications Council; and is Secretary General of the Global Allergy and Asthma European Network. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2016
The Authors. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 138 - N° 2
P. 367 - août 2016 Retour au numéro
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