Pharmacotherapy for Obesity - 11/08/16
, Alpana P. Shukla, MD, MRCP (UK), Leon I. Igel, MD, DABOM, Rekha B. Kumar, MD, MS, DABOM, Louis J. Aronne, MD, DABOM, FTOSRésumé |
Successful treatment of obesity requires a multidisciplinary approach including diet, exercise and behavioral modification. As lifestyle changes are not sufficient for some patients, pharmacologic therapies should be considered as adjuncts to lifestyle interventions. In this article, we review clinical indications, mechanisms of action, dosing/administration, side effects, drug interactions and contraindications for the six most widely prescribed obesity medications. We also summarize the efficacy data from phase 3 trials which led to drug approval. As multiple agents are sometimes required for clinically significant weight loss, the future of obesity medicine will likely involve combinations of agents in addition to behavioral counseling.
Le texte complet de cet article est disponible en PDF.Keywords : Obesity, Weight management, Pharmacotherapy, Orlistat, Phentermine/topiramate ER, Lorcaserin, Naltrexone SR/bupropion SR, Liraglutide
Plan
| Disclosure Statement: Katherine H. Saunders, Alpana P. Shukla and Leon I. Igel declare that they have no conflict of interest. Rekha B. Kumar is a speaker for Jansen Pharmaceuticals and a shareholder in Zafgen and Myos Corporation. Louis J. Aronne declares consultant/advisory board work with Jamieson Labs, Pfizer Inc, Novo Nordisk A/S, Eisai, VIVUS, GI Dynamics, JOVIA Health, and Gelesis. He is a shareholder of Zafgen, Gelesis, Myos Corporation, and Jamieson Labs, and he is on the Board of Directors of MYOS Corporation and Jamieson Labs. He has received research funding from Aspire Bariatrics and Eisai. |
Vol 45 - N° 3
P. 521-538 - septembre 2016 Retour au numéro
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