Influence of dexmedetomidine on cognitive function in volunteers - 21/08/16
, Takahiko Tamura, MD, PhD, Koichi Yamashita, MD, PhD, Masataka Yokoyama, MD, PhDAbstract |
Study objective |
Some outpatient procedures are performed under sedation with dexmedetomidine, although the effect of dexmedetomidine on cognitive function remains unclear. This study investigated the effect of dexmedetomidine on cognitive function in healthy volunteers.
Design |
Observation study in volunteers.
Setting |
University-affiliated teaching hospital.
Patients |
Six healthy volunteers.
Interventions |
After infusion of a 6-μg/kg per hour loading dose of dexmedetomidine for 10 minutes, a maintenance infusion of 0.4 μg/kg per hour was administered for 4 hours.
Measurements |
Cognitive function was evaluated before infusion (baseline) and at 2, 4, 6, and 8 hours after infusion. Cognitive function, response speed, accuracy, and consistency were measured by CogHealth. Depth of sedation was evaluated at 1-hour intervals by evaluating the Bispectral Index. Data are presented as the change from baseline.
Main results |
The Bispectral Index value was significantly lower from 10 minutes to 6 hours after infusion versus the pre-infusion value. Response speed was also significantly lower at 2 hours and 4 hours after infusion (92 ± 8%, P< .0001; 93 ± 6%, P< .0001), as was consistency (96 ± 7%, P= .0009; 96 ± 5%, P= .0003). Response accuracy was unaltered by the infusion.
Conclusions |
Dexmedetomidine slightly reduced response speed and consistency, but did not affect response accuracy. Cognitive function was restored to pre-administration values 2 hours after the infusion of dexmedetomidine was discontinued.
Le texte complet de cet article est disponible en PDF.Highlights |
• | This is the first study about between cognitive function and dexmedetomidine in detail. |
• | Response speed and consistency during infusion was lower. |
• | Accuracy of responses did not change during infusion of dexmedetomidine. |
• | Cognitive function recovered 2 hours after the infusion of this drug was discontinued. |
Keywords : Cognitive function, Dexmedetomidine, Volunteer
Plan
| ☆ | Disclosure of funding received for the work: Kochi Medical School Hospital. |
| ☆☆ | Disclosures: The authors certify that there is no conflict of interest with any financial organization. |
Vol 33
P. 92-96 - septembre 2016 Retour au numéro
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