Withdrawn/Depressed Behaviors and Error-Related Brain Activity in Youth With Obsessive-Compulsive Disorder - 22/09/16
, Yanni Liu, PhD a, Yona E. Isaacs, BS a, Angela M. Ayoub, MSW a, Jose J. Torres, MS a, Nolan B. O’Hara, MS b, William J. Gehring, PhD aAbstract |
Objective |
The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate cortex with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response that is believed to reflect anterior cingulate cortex activity. This study examined the relation of the ERN to OCD symptom dimensions and other childhood symptom dimensions.
Method |
The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 80 youth with a lifetime diagnosis of OCD and 80 matched healthy comparison participants ranging from 8 to 18 years old. The relation of the ERN to OCD symptom dimension scores and Child Behavior Checklist Syndrome Scale scores was examined in multiple linear regression analyses.
Results |
Accuracy was significantly decreased and ERN amplitude was significantly increased in patients compared with controls. ERN amplitude in patients was significantly correlated with accuracy, but not with OCD symptom dimensions, severity, comorbidity, or treatment. In a multiple linear regression analysis using age, accuracy, OCD, and Child Behavior Checklist Syndrome Scale scores as predictors of ERN amplitude, the ERN had significant associations only with Withdrawn/Depressed Scale scores and accuracy.
Conclusion |
An enlarged ERN is a neural correlate of pediatric OCD that is independent of OCD symptom expression and severity. The finding of lower accuracy in pediatric cases requires replication. The relation between an enhanced ERN and withdrawn/depressed behaviors warrants further research in youth with OCD and other internalizing disorders.
Le texte complet de cet article est disponible en PDF.Key words : error-related negativity, biomarker, obsessive-compulsive disorder, Child Behavior Checklist, symptom dimensions
Plan
| This research was supported by National Institute of Mental Health grants R01 MH085321 (G.L.H.) and R01 MH101493 (G.L.H. and W.J.G.). |
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| Brenda W. Gillespie, PhD, served as the statistical expert for this research. |
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| The authors thank Brenda W. Gillespie, PhD, of the University of Michigan, for statistical consultation. |
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| Disclosure: Drs. Hanna, Liu, Gehring, Ms. Isaacs, Ms. Ayoub, Mr. Torres, and Mr. O’Hara report no biomedical financial interests or potential conflicts of interest. |
Vol 55 - N° 10
P. 906 - octobre 2016 Retour au numéro
Article précédent
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