Effect of age at rheumatoid arthritis onset on clinical, radiographic, and functional outcomes: The ESPOIR cohort - 24/09/16
, Adeline Ruyssen-Witrand a, b, Delphine Nigon a, Yannick Degboe a, Gabriel Tobon c, Bruno Fautrel d, e, Francis Berenbaum f, g, Alain Cantagrel a, Arnaud Constantin a, bBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objectives |
To investigate whether age at disease onset determines clinical, radiographic or functional outcomes in a cohort of early RA.
Methods |
The ESPOIR cohort is a multicenter cohort of patients with early arthritis. We selected patients fulfilling the 2010 ACR/EULAR criteria for RA during the first 3years of follow-up. Patients were pooled into 3 groups by age at RA onset: <45years (young-onset RA [YORA]), 45 to 60years (intermediate-onset RA [IORA]) and>60years (late-onset RA [LORA]). The following outcomes were compared at baseline and during the first 3years of follow-up: Simple Disease Activity Index (SDAI) remission rate, one additional erosion, Health Assessment Questionnaire Disability Index (HAQ-DI)<0.5 and first disease-modifying anti-rheumatic drug (DMARD) continuation rate.
Results |
We included 698 patients (median [interquartile range] age 50.3 [39.8–57.2]years), 266 YORA, 314 IORA, and 118 LORA. At 1year, SDAI remission was greater for YORA than IORA and LORA (P<0.0001). Having at least one additional erosion was greater for LORA and IORA than YORA after 1year (P=0.009) and 3years (P=0.017). The proportion of patients with HAQ score<0.5 was greater for YORA than IORA and LORA at 1 (P=0.007), 2 and 3years. First DMARD continuation rate was lower for YORA than other groups during the 3years (P=0.005).
Conclusions |
In a cohort of early RA, young age at disease onset is associated with high rate of remission at 1year, no radiographic progression at 3years and low functional score during 3-year follow-up.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Clinical remission, Treatment modalities, Radiography, Radiographic progression, Health Assessment Questionnaire
Plan
Vol 83 - N° 5
P. 511-515 - octobre 2016 Retour au numéro
Article précédent
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