Insomnia may increase anesthetic requirement - 12/10/16
: Associate Professor, Süheyla Abitağaoğlu, MD : Specialist, Cihan Güler, MD ⁎ : Assistant Doctor, Zuhal Doğan, MD : Assistant Doctor, Şenay Kırgezen, MD : Specialist, Yeşim Abut, MD : Chief Assistant, SpecialistAbstract |
Study Objective |
Gamma aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. It is a common target for general anesthetics, and it is strongly related to the etiology of chronic insomnia. In this study, we aimed to investigate whether insomnia has any effect on anesthetic requirement, and we also assessed pain to reveal a relationship with insomnia.
Design |
This study designed as a prospective, observational study, registered ANZCTR (ACTRN12616000241437), with institutional review board approval and written informed consent.
Setting |
Preoperative and postoperative areas of the training and research hospital.
Patients |
Inpatients planning to undergo laparoscopic cholecystectomy as an elective surgery were enrolled in this study.
Interventions |
Patients were divided into 2 groups based on the results of the 4-item Jenkins Sleep Questionnaire which assesses the degree of sleep disturbance: those with or without insomnia. Anesthesia was standardized, and delivered sevoflurane concentration was adjusted according to bispectral index (BIS) value in both groups.
Measurements |
Parameters of the study were heart rate, noninvasive arterial blood pressure, arterial oxygen saturation, BIS, end-tidal carbon dioxide, and inspiratory and end-tidal concentrations of sevoflurane at 5-minute intervals during the operation. Pain was assessed for all participants; preoperatively using 2-sided blank body manikin (front and back) and postoperatively with numeric rating scale between 0 and 10.
Main Results |
End-tidal concentration of sevoflurane found higher in insomnia group during the maintenance phase of anesthesia. Pain experience was higher in insomnia group. In addition, postoperative abdominal pain score was higher only at 18-hour interval in insomnia group. Although BIS values were similar in both groups during surgery, mean end-tidal sevoflurane concentrations were significantly higher in insomnia group (1.48±0.20) than control group (1.23±0.18) (P<.0001).
Conclusion |
Insomnia may result in increased anesthetic requirement and pain experience. Further study is required to identify the relationship between insomnia and anesthetics.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Evaluated anesthetic requirement for insomniacs and patients with no sleep problems. |
• | Hypothesis was that insomnia has an effect on anesthetic requirement. |
• | Mean end-tidal sevoflurane concentrations during operation were higher in the insomnia group. |
• | Bispectral index values were similar during surgery in both groups. |
• | Anesthetic requirement was increased in insomnia group. |
Keywords : Insomnia, General anesthesia, Sevoflurane, Bispectral index, γ-Aminobutyric acid
Plan
| ☆ | There is no conflict of interest for all authors. |
| ☆☆ | We did not receive any support from an organization for this study. |
Vol 34
P. 367-372 - novembre 2016 Retour au numéro
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